Efficient preparation of high-quality 64Cu for routine use

Ohya, Tomoyuki; Nagatsu, Kotaro; Suzuki, Hisashi; Fukada, Masami; Minegishi, Katsuyuki; Hanyu, Masayuki; Fukumura, Toshimitsu; Zhang, Ming‐Rong

doi:10.1016/j.nucmedbio.2016.07.007

Cited by 49 publications

(61 citation statements)

References 27 publications

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“…With up to 133 GBq μmol −1 , our method generates moderate values, higher than those reported by Jeffery et al., Matarrese et al . and Obata et al., but lower than those achieved by Avila‐Rodriguez et al., McCarthy et al., Ohya et al . and Thieme et al .…”

Section: Resultscontrasting

confidence: 51%

“…Ohya et al [67] 1170 AE 1170 ICP-MS Avila-Rodriguez etal. [46] 696 AE 122 Titration with TETA Thiemee tal.…”

Section: Measurementmethodsmentioning

confidence: 99%

“…Ta ble 3s hows ac omparison between the resultsp resented in this study and previously publishedm olar activities of other groups. With up to 133 GBq mmol À1 ,o ur method generates moderate values, higher than those reportedb yJ effery et al, [45] Matarrese et al [48] and Obata et al, [62] but lower than those achieved by Avila-Rodrigueze tal., [46] McCarthy et al, [19] Ohya et al [67] and Thiemee tal. [44] Our results can best be compared with those of Matarrese et al, [48] who also worked with the Alceo modules.…”

Section: Characterizationmentioning

confidence: 99%

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Fully Automated Production and Characterization of ⁶⁴Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using ⁶⁴Cu‐Labelled CA XII Targeting 6A10 Fab

et al. 2018

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Cu is a cyclotron-produced radionuclide which offers, thanks to its characteristic decay scheme, the possibility of combining positron emission tomography (PET) investigations with radiotherapy. We evaluated the Alceo system from Comecer SpA to automatically produce Cu for radiolabelling purposes. We established a Cu production routine with high yields and radionuclide purity in combination with excellent operator radiation protection. The carbonic anhydrase XII targeting 6A10 antibody Fab fragment was successfully radiolabelled with the produced Cu, and proof-of-principle small-animal PET experiments on mice bearing glioma xenografts were performed. We obtained a high tumor-to-contralateral muscle ratio, which encourages further in vivo investigations of the radioconjugate regarding a possible application in diagnostic tumor imaging.

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Section: Resultscontrasting

confidence: 51%

“…Ohya et al [67] 1170 AE 1170 ICP-MS Avila-Rodriguez etal. [46] 696 AE 122 Titration with TETA Thiemee tal.…”

Section: Measurementmethodsmentioning

confidence: 99%

Section: Characterizationmentioning

confidence: 99%

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Fully Automated Production and Characterization of ⁶⁴Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using ⁶⁴Cu‐Labelled CA XII Targeting 6A10 Fab

et al. 2018

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“…Production techniques for 61,64 Cu are well developed and typically make use of the 61 Ni(p,n) 61 Cu and 64 Ni(p,n) 64 Cu reactions . Gold or silver target backings are electroplated with enriched Ni target material from electroplating baths composed of nickel sulfate or nickel chloride …”

Section: Radiometals For Theranostic Applicationsmentioning

confidence: 99%

“…114 Production techniques for 61,64 Cu are well developed and typically make use of the 61 Ni(p,n) 61 Cu and 64 Ni(p, n) 64 Cu reactions. 115,116 Gold or silver target backings are electroplated with enriched Ni target material from electroplating baths composed of nickel sulfate or nickel chloride. 115 Irradiations are typically carried out with 8 to 14 MeV protons to make use of the high reaction cross section over these energies (Figure 1).…”

Section: Zrmentioning

confidence: 99%

Radiometals for imaging and theranostics, current production, and future perspectives

Mikołajczak

Meulen

Lapi

2019

Labelled Comp Radiopharmac

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The aim of this review is to make the reader familiar with currently available radiometals, their production modes, capacities, and quality concerns related to their medical use, as well as new emerging radiometals and irradiation technologies from the perspective of their diagnostic and theranostic applications. Production methods of 177Lu serve as an example of various issues related to the production yield, specific activity, radionuclidic and chemical purity, and production economy. Other radiometals that are currently used or explored for potential medical applications, with particular focus on their theranostic value, are discussed. Using radiometals for diagnostic imaging and therapy is on the rise. The high demand for radiometals for medical use prompts investigations towards using alternative irradiation reactions, while using existing nuclear reactors and accelerator facilities. This review discusses these production capacities and what is necessary to cover the growing demand for theranostic nuclides.

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Implementation of a new separation method to produce qualitatively improved ⁶⁴Cu

Meulen

Hasler

Blanc

et al. 2019

Labelled Comp Radiopharmac

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Background 64Cu (T1/2 = 12.7 h) is an important radionuclide for diagnostic purposes and used for positron emission tomography (PET). A previous method utilized at Paul Scherrer Institute (PSI) proved to be unreliable and, while a method using anion exchange chromatography is a popular choice worldwide, it was felt a different approach was required to obtain a robust chemical separation method. Methods Enriched 64Ni targets were created by electroplating on gold foil. The targets were irradiated with protons degraded to approximately 11 MeV at PSI's Injector 2 72 MeV research cyclotron and subsequently dissolved in HCl. The resultant solution was loaded onto AG MP‐50 cation exchange resin and the 64Cu separated from its target material and radiocobalt impurities, produced as part of the irradiation process, using various specific mixtures of HCl/acetone solution. The eluted product was evaporated and picked up in dilute HCl (0.05 M). The chemical purity of 64Cu was determined by radiolabeling experiments at the highest possible molar activities. Results Reproducible results were obtained, yielding 3.6 to 8.3 GBq 64Cu of high radionuclidic and radiochemical purity. The product was labeled to NODAGA‐RGD, achieved at up to 500 MBq/nmol, indicating the high chemical purity. In a proof‐of‐concept in vivo study, 64Cu‐NODAGA‐RGD was used for PET imaging of a tumor‐bearing mouse. Conclusion The chemical separation devised to produce high‐quality 64Cu proved to be robust and reproducible. The concept can be used at medical cyclotrons utilizing a solid target station, such that 64Cu can be used at hospitals for PET imaging.

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Efficient preparation of high-quality 64Cu for routine use

Cited by 49 publications

References 27 publications

Fully Automated Production and Characterization of ⁶⁴Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using ⁶⁴Cu‐Labelled CA XII Targeting 6A10 Fab

Fully Automated Production and Characterization of ⁶⁴Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using ⁶⁴Cu‐Labelled CA XII Targeting 6A10 Fab

Radiometals for imaging and theranostics, current production, and future perspectives

Implementation of a new separation method to produce qualitatively improved ⁶⁴Cu

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Efficient preparation of high-quality 64Cu for routine use

Cited by 49 publications

References 27 publications

Fully Automated Production and Characterization of 64Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using 64Cu‐Labelled CA XII Targeting 6A10 Fab

Fully Automated Production and Characterization of 64Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using 64Cu‐Labelled CA XII Targeting 6A10 Fab

Radiometals for imaging and theranostics, current production, and future perspectives

Implementation of a new separation method to produce qualitatively improved 64Cu

Contact Info

Product

Resources

About

Fully Automated Production and Characterization of ⁶⁴Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using ⁶⁴Cu‐Labelled CA XII Targeting 6A10 Fab

Fully Automated Production and Characterization of ⁶⁴Cu and Proof‐of‐Principle Small‐Animal PET Imaging Using ⁶⁴Cu‐Labelled CA XII Targeting 6A10 Fab

Implementation of a new separation method to produce qualitatively improved ⁶⁴Cu