Efficient Preparation of ortho-Aminobenzenesulfonamides using Ligand-Free Copper(I)-Catalyzed Amination

Abstract

A general and efficient method of copper-catalyzed amination of 2-iodobenzenesulfonamide has been developed under very mild conditions, with good to excellent yields. This method uses inexpensive copper(I) iodide as catalyst, readily available 2-iodobenzenesulfonamides and aliphatic amines as the starting materials, and does not require the use of any ligand system or any expensive supplementary additives.