Efficient production of Antrodin C by microparticle-enhanced cultivation of medicinal mushroom Antrodia cinnamomea

Fan, Jiahui; Lai, Ke-Sheng; Huang, Yue-Ying; Xiong, Lin-Qiang; Guo, Huang-Kai; Yang, Qiong-Qiong; Zhang, Bobo

doi:10.1016/j.jbiosc.2022.12.013

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…For tissue-specific metabolites, secondary metabolites biosynthesis pathway genes were enriched, including 14-α-demethylase (CYP51F1) for the conversion of lanosterol to ergosteroidal triterpenes in fruiting bodies, coenzyme Q (COQ) for the synthesis of antroquinonol in mycelia, and polyketide synthase for the synthesis of antrocamphin in fruiting bodies. It was reported that talc enhanced the yield of the bioactive secondary metabolite antioxidant antrodin C in the submerged fermentation of AC by increasing the permeability and fluidity of the cell membrane, upregulating the key genes and then improving the biosynthesis process ( Fan J. H. et al, 2023 ). Another study showed that oxidative stressors supplementation (such as hydrogen peroxide) can increase the yield of antrodin C in submerged fermentation of AC ( Hu et al, 2020 ).…”

Section: Future Perspectivesmentioning

confidence: 99%

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

Li,

Wan,

Qiao

et al. 2024

Front. Pharmacol.

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Prevalent neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and stroke are increasingly becoming a global burden as society ages. It is well-known that degeneration and loss of neurons are the fundamental underlying processes, but there are still no effective therapies for these neurological diseases. In recent years, plenty of studies have focused on the pharmacology and feasibility of natural products as new strategies for the development of drugs that target neurological disorders. Antrodia camphorata has become one of the most promising candidates, and the crude extracts and some active metabolites of it have been reported to play various pharmacological activities to alleviate neurological symptoms at cellular and molecular levels. This review highlights the current evidence of Antrodia camphorata against neurological disorders, including safety evaluation, metabolism, blood-brain barrier penetration, neuroprotective activities, and the potential on regulating the gut-microbiome-brain axis. Furthermore, potential strategies to resolve problematic issues identified in previous studies are also discussed. We aim to provide an overview for the ongoing development and utilization of Antrodia camphorata in cerebral neuropathology.

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Section: Future Perspectivesmentioning

confidence: 99%

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

Li,

Wan,

Qiao

et al. 2024

Front. Pharmacol.

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“…During fermentation, the higher the oxygen supply, the more the APSs produced and the shorter the culture period (Shih et al, 2006). In addition, the microparticle-enhanced cultivation technology can be used to increase the yield of bioactive compounds from A. cinnamomea in submerged fermentation (Fan et al, 2023).…”

Section: Production Of Apssmentioning

confidence: 99%

Extraction, isolation, identification, and bioactivity of polysaccharides from Antrodia cinnamomea

Dai,

Liu,

et al. 2023

Qual. Assur. Saf. Crops Foods

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Antrodia (A) cinnamomea is a precious edible and medicinal mushroom and has attracted attention because of its rare resources and unique bioactivities. The bioactive compounds from the fruit body, mycelium, and fermentation broth of A. cinnamomea include triterpenoids, polysaccharides, antroquinonols, benzenoids, and succinic and maleic acid derivatives. Among these, polysaccharides are very important and are high-content bioactive compounds. The A. cinnamomea polysaccharides (APSs) present numerous biological activities, such as antiviral, anticancer, anti-inflammatory, antivascular, immunoregulation, antioxidant, and nerve protection. However, only few studies have focused only on APSs so far. Therefore, the cultivation methods, extraction, isolation, composition, structure, biological activity, and application of APSs are summarized in this review to provide a comprehensive and convenient reference for further research and development on APSs.

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“…It belongs to the phylum Basidiomycetes, the family Polyporaceae, and the genus Taiwanofungus. Its fruiting bodies contain triterpenoids [1,2], polysaccharides [3], adenosine [4], proteins [5], and many active ingredients, giving it significant anticancer [6,7], antihepatoma [8], antitumor [9], anti−inflammatory [10], antifatigue [11], and liver−protecting [12] properties. However, despite their well−known medicinal properties, the fruiting bodies and mycelia of T. camphoratus grow slowly and have obvious host specificity, taking up to 3-5 years to reach maturity.…”

Section: Introductionmentioning

confidence: 99%

Cymbopogon citratus Water Extract and Methyl Jasmonate Improve Polyunsaturated Fatty Acid Metabolism in Taiwanofungus camphoratus Mycelia

Wen,

Lin,

Lin

et al. 2024

Separations

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A rare medicinal fungus called Taiwanofungus camphoratus gives people resistance to illness. In order to effectively obtain high−quality T. camphoratus mycelia, we added Cymbopogon citratus (lemongrass) water extract (LWE), which was prepared using hot water and dry lemongrass leaves and methyl jasmonate (MJ) as an additive, in order to cultivate T. camphoratus mycelia. The components of LWE were identified by gas chromatography–mass spectrometry as glucose (61.66%) and galactose (17.10%). Compare to the basal medium, 0.5–2.5 g·L−1 LWE and 5–25 μmol·L−1 MJ can enhance the proliferation of mycelia and the metabolism of polyunsaturated fatty acids (PUFAs). Among them, the T. camphoratus mycelia growth rate increased to 1.292 ± 0.01 cm·d−1 and 1.285 ± 0.05 cm·d−1, improving by 2.5 g·L−1 LWE and 25 μmol·L−1 MJ, respectively. PUFAs are mainly composed of linoleic acid (LA) and oleic acid (OA). The contents of LA and OA were 0.28 ± 0.02 mg·g−1 and 0.23 ± 0.05 mg·g−1 after MJ treatment, while the contents of LA and OA were 0.08 ± 0.03 mg·g−1 and 0.05 ± 0.05 mg·g−1 after LWE treatment. Transcriptome analyses revealed that 367 and 232 genes within MJ and LWE treatment were significantly different from the basal medium. Out of 13 unigenes, FAD2−2, SCD, and FAD2−1 had the highest expression levels according to the quantitative RT−PCR result. The bioinformatics analysis showed that three genes are closely related to the M8 chromosome of T. camphoratus, and they are hydrophobic transmembrane proteins. The identification and investigation of fatty acid genes in T. camphoratus mycelia will be improved by our findings.

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Efficient production of Antrodin C by microparticle-enhanced cultivation of medicinal mushroom Antrodia cinnamomea

Cited by 5 publications

References 24 publications

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

Extraction, isolation, identification, and bioactivity of polysaccharides from Antrodia cinnamomea

Cymbopogon citratus Water Extract and Methyl Jasmonate Improve Polyunsaturated Fatty Acid Metabolism in Taiwanofungus camphoratus Mycelia

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