Efficient Synthesis and Antiproliferative Evaluation of New Bioactive N-, P-, and S-Heterocycles

Mansour, Shaimaa T.; Abd‐El‐Maksoud, Mansoura A.; El‐Hussieny, Marwa; Awad, Hanem M.; Hashem, Ahmed I.

doi:10.1134/s1070363222090183

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…The developing brain is highly vulnerable to oxidation stress induced injury due to its great lipid content and high oxygen consumption. Neuronal exposure to oxidation stress enhances lipid peroxidation that may alter membrane excitability, disturb neurotransmitters and impairs both morphological and functional aspects of developing brain [1][2][3][4][5][6]. Production of free radicals and reactive oxygen/nitrogen species is tightly regulated by physiological anti-oxidant defense.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2024

J. Med. Chem. Sci.

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Background: Cognitive impairment represents a major but underdetermined comorbidity in children with temporal lobe epilepsy. Exposure to oxidation stress may induce cellular damage and functional disruption in the developing brain. Method: This comparative study included 42 children with newly diagnosed temporal lobe epilepsy and 42 healthy children as a control group. Cognition was assessed using Wechsler Intelligence Scale. Malondialdehyde and Advanced Oxidation Protein Products were measured as markers for oxidants while plasma catalase and total antioxidant capacity was measured as markers for antioxidants. Biomarkers of oxidation stress were correlated to clinical data and cognition scores of included children. Results: Children with temporal lobe epilepsy have significant higher circulating malondialdehyde, Advanced Oxidation Protein Products and lower catalase, total anti-oxidant capacity, and cognition ability scores than healthy controls. Cognition ability scores have significant negative correlation with malondialdehyde and Advanced Oxidation Protein Products levels and significant positive correlation with the age of onset of seizures, plasma catalase and total anti-oxidant capacity levels. Conclusion: Oxidation stress may be associated with decreased cognitive abilities in children with newly diagnosed temporal lobe epilepsy. Treatment strategy for children with newly diagnosed temporal lobe epilepsy should be adjusted to decrease oxidation stress to avoid worsening of cognitive function.

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Section: Introductionmentioning

confidence: 99%

Untitled

2024

J. Med. Chem. Sci.

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Synthesis of 2-Azetidinones via Cycloaddition Approaches: An Update

Cordero,

Giomi,

Machetti

2024

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The present review is a comprehensive update of the synthesis of monocyclic β-lactams via cycloaddition reactions. According to the IUPAC definition of cycloaddition, both elementary and stepwise processes (formal cycloadditions) have been considered. The years 2019–2022 are covered by the cited literature. The focus of the review is on synthetic aspects with emphasis on the structural scope, reaction conditions, mechanistic aspects, and selectivity results. Selected significant data related to biological activities and synthetic applications are also highlighted.

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Efficient Synthesis and Antiproliferative Evaluation of New Bioactive N-, P-, and S-Heterocycles

Cited by 2 publications

References 34 publications

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Synthesis of 2-Azetidinones via Cycloaddition Approaches: An Update

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