Efficient synthesis of 1-alkyl -2, 3, 4, 5-tetramethoxy-6-methylbenzene: key intermediate for preparing coenzyme Q analogues

Abstract

This paper described a convenient and efficient route for the synthesis of 1-alkyl-2, 3, 4, 5-tetramethoxy-6-methylbenzene, which are the key intermediate for the synthesis of C-6 substituted Coenzyme Q analogues. All the reactions are operationally simple and amenable to gram-scale synthesis.

A convenient synthesis of 1-aralkyl-4-benzylpiperazine derivatives

“…The mixture was cooled and the precipitated piperazine dihydrochloride Spectroscopic data are according to the literature. 13 Synthesis of compounds 6a-c: general procedure [14][15][16][17] Hydrochloric acid (3 mL, 37%) was added to a stirred mixture of 5a-c (0.010 mol) and paraformaldehyde (0.45 g, 0.015 mol) at room temperature. The mixture was stirred at 35 °C for 1 h, water (10 mL) was then added and the mixture was extracted with petroleum ether (b.p.…”