Efficient synthesis of 2,3,4,5-tetramethoxy-6-methylbenzoic acid

A convenient synthesis of 1-aralkyl-4-benzylpiperazine derivatives

“…Compounds 5a-c were prepared according to literature procedures. [6][7][8][9][10] Synthesis of N-benzylpiperazine (4) A solution of anhydrous piperazine (1, 9.4 g, 0.11 mol) and piperazine dihydrochloride (2, 31.8 g, 0.20 mol) in ethanol (80 mL) was placed in a three-necked flask equipped with a magnetic stir bar and reflux condenser and was heated with vigorous stirring at 65 °C for 3 h. Then benzyl chloride (12.6 g, 0.10 mol) was added dropwise over a period of 45 min to the reaction mixture, which was then refluxed for another 2 h. The progress of the reaction was monitored by TLC. The mixture was cooled and the precipitated piperazine dihydrochloride Spectroscopic data are according to the literature.…”

Practical synthesis of 2-(4-benzyl-piperazin-1-ylmethyl)-5, 6-dimethoxy-3-methyl-[1, 4]benzoquinone hydrochloride

“…benzoquinone 7 were prepared by the literature method[4][5][6][7][13][14][15][16][17][18][19][20][21].…”