Efficient Synthesis of Arylidene Heterobicyclic Pyrimidinone via Ferric Chloride Catalyzed Biginelli-Type Reaction

Abstract

Pyrimidinone and its functionalized derivatives are known to possess a broad-spectrum of biological activities. This paper described an efficient method for the synthesis of pyrimidinones via ferric chloride catalyzed Biginelli-type condensation of aromatic aldehyde, cyclopentanone, and urea or thiourea. The reactions produce a series of arylidene heterobicyclic pyrimidinones in moderate to excellent yields under solvent-free conditions.