Efficient synthesis of benzothiazine and acrylamide compounds

Abstract

This article describes the synthesis of the new (2Z)-2-(4-methoxybenzylidene)-6-nitro-4H -benzo[1,4]thiazin-3-one, (2Z)-2-(4-methoxybenzylidene)-4-methyl-6-nitro-4H-benzo[1,4]thiazin-3-one, (2Z)-6-amino-2-(4-methoxybenzylidene)-4H -benzo[1,4]thiazin-3-one, (2Z)-6-butylamino-2-(4-methoxybenzylidene)-4-methyl-4H-benzo[1,4]-thiazin-3-one and (2E)-N-alkyl-N-(2-hydroxy-5-nitrophenyl)-3-phenylacrylamides and the spectroscopic data. The arylidenebenzothiazine compounds were prepared using the Knoevenagel condensation with substituted benzaldehydes in the presence of sodium methoxide in DMF. The presence of a nitro substituent in the 4-position, water and a slightly acid reaction medium in this condensation caused the rupture of the benzothiazine ring and subsequent formation of the phenylacrylamide compounds. A crystallographic data was presented for (2E)-3-(4-bromophenyl)-N-dodecyl-N -(2-hydroxy-5-nitrophenyl) acrylamide

Total determination and direct chemical speciation of Hg in fish by solid sampling GF AAS

“…5 Besides this, the human organism is capable of eliminating MHg or decreasing the toxicity symptoms, since genetic factors (age, sex, hormones, hemoglobin production and metallothioneins induction) can act as protector barriers of MHg accumulation in the brain and cerebellum. 20 The direct chemical speciation of Hg 2+ and MHg in fish is possible using SS-GF AAS and appropriate chemical modifiers. The detection and quantification limits and characteristic masses are shown in Table 5, using two different chemical modifiers.…”

Base induced synthesis of 4H-1,4-benzothiazines and their computational studies

“…1 Amongst these, six membered heterocycles especially 1,4-benzothiazines, owing to the presence of nitrogen, carbon and sulfur linkages, have attained importance due to their wide range of applications in different elds like the pharmaceutical, medicinal, therapeutic and agricultural elds etc. 2 1,4-Benzothiazine derivatives possess numerous biological activities viz. antibiotic, anticancer, antiviral, antifungal, antimicrobial, antiparkinson, anti-inammatory, antihypertensive, antitumor, anti-aldose reductase, anti-rheumatic, anti-arrhythmic, anti-HIV and anti-allergy activity etc.…”

“…Ultrasonication enables optimization, avoids toxicity, reduces multistep reactions to a single step, and forms less byproducts. [2][3][4][5][6]9,[11][12][13][14][15] The present paper discusses the synthesis of 1,4-benzothiazine derivatives using a greener synthetic pathway, i.e. an ultrasonication method, and their characterization using NMR, IR, UV-vis and uorescence spectroscopy and mass spectrometry.…”