Efficient synthesis of bisulfide-bridged bicyclopeptides by intramolecular photoinduced electron transfer cycloreaction

Abstract

A facile methodology for synthesis of bicyclopeptides containing isoindolone was developed by intramolecularly photo-induced electron transfer cyclo-reaction (IPETC) with high yield and stereoselectivity. Nine bisulfide-bridged bisisodindolone-cyclopeptides were successfully prepared based...