Efficient synthesis of differently substituted triarylpyridines with the Suzuki-Miyaura cross-coupling reaction

Abstract

A library of differently substituted 3,4,5-triaryl-2,6-dimethylpyridines and 2,3,5-triaryl-4,6-dimethylpyridines were synthesized and characterized using the Suzuki-Miyaura cross-coupling reaction with accordingly selected tribromodimethylpyridines and arylboronic acids. The optimized coupling conditions were found to be general for both isomeric tribromodimethylpyridines and a wide range of arylboronic acids substituted with electro-donating and electro-withdrawing groups.