Efficient Synthesis of Thieno[2,3-d]Pyrimidines and Related Fused Systems

Abstract

The synthetic potency of readily accessible, ethyl 2-amino-4-methyl-5-(4-nitrophenoxy)thiophene-3-carboxylate (1) as a versatile precursor for the synthesis of novel polyfunctionally substituted thienopyrimidines is reported. The latter derivatives undergo further heterocyclisation to the related polycyclic fused systems via reactions with different reagents.

Facile Synthesis of Novel Amino Acids Derivatives as Potential Antibacterial Agents using Sustainable Materials

“…Guided by the previous observations, and in continuation of our ongoing interest in the synthesis of biologically active molecules, several new cardanol derivatives conjugated with flexible protected and unprotected amino acids as side chains have been designed. This combination has been suggested as an effective means of evaluating the effect of different amino acids on the bioactivity of cardanol derivatives, and therefore these products were tested for their antibacterial activity.…”

Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents

“…Prompted by the varied biological activities of triazole derivatives and in continuation of our efforts for the synthesis of biologically active heterocycles [27][28][29], the present work describes the synthesis of novel 1,2,4-triazole derivatives attached with quinoline moiety with the aim of enhancement of their biological activity.…”

A convenient synthesis of novel amino acid derivatives with potential antibacterial activity using sustainable materials

“…They are used also as reactive substrates in the design of bioactive molecules for cancer treatment. [23][24][25] Guided by previous observations and in continuation of our ongoing interest in the synthesis of biologically active molecules, [26][27][28][29][30] several new cardanol derivatives conjugated with flexible protected and unprotected amino acids as side chains have been designed. This combination was suggested as an effective means of evaluating the effect of different amino acids on the bioactivity of cardanol derivatives, and subsequently these products were tested for their antibacterial activity.…”