Efficient Synthetic Access to Novel Indolo[2,3-b]Quinoxaline-based Heterocycles

Abeed, Ahmed Abdou O.; El‐Emary, Talaat I.; Alharthi, Sarah

doi:10.2174/1570179418666210809144906

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Furthermore, the pyridine ring appears in a wide range of synthetic chemistry [21,22], including agrochemicals and insecticides [23][24][25][26][27][28]. As a result of the aforementioned and continuing teamwork [29][30][31][32][33][34][35][36], we are interested in developing novel 2-pyrazoline or pyridine analogs combining pyrazolopyridine and pyrazole nuclei having molluscicidal activity against the land snail, T. pisana. (Fig.…”

Section: Introductionmentioning

confidence: 99%

Novel synthesis of some heterocycles and their molluscicidal activity against the destructive land snail, Theba pisana

Abeed,

El-Emary,

Youssef

et al. 2024

Chem. Biol. Technol. Agric.

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Background Terrestrial snails, specifically Theba pisana, represent significant agricultural pests in the Mediterranean region, particularly in Egypt. They are gastropods that cause substantial damage to a variety of vegetation, rendering them important agricultural pests that result in economic losses. In response, we have developed unique and non-toxic molluscicides. The study assessed nine novel heterocycles compared with methomyl as a reference compound, to study their molluscicidal effects on T. pisana. These heterocycles include 2-pyrazolines, 2-oxocyclohex-3-ene, and 3-cyano-2-ethoxypyridine. Results The obtained data revealed that the majority of the produced chemicals were remarkably effective against T. pisana snails, exhibiting different degrees of toxicity seven days post-treatment. Methomyl exhibited the highest toxicity, followed by prop-2-en-1-one and 1-thiocarbamoyl-2-pyrazoline derivatives, with LC50 values of 44.14, 59.54, and 72.00 ppm, respectively. Conclusions These findings will inform the potential of these synthetic compounds as one of the sources for molluscicide development and their integration into pest management strategies. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Novel synthesis of some heterocycles and their molluscicidal activity against the destructive land snail, Theba pisana

Abeed,

El-Emary,

Youssef

et al. 2024

Chem. Biol. Technol. Agric.

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Biological activities of novel 2-pyrazolin-5-one derivatives and their toxicity on certain pests infesting field crops in laboratory conditions

Abeed,

El Shamy,

Abd El-Wahed

et al. 2024

Journal of King Saud University - Science

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Multi-Lasso Peptide-Based Synergistic Nanocomposite: A High-Stability, Broad-Spectrum Antimicrobial Agent with Potential for Combined Antibacterial Therapy

Li,

Zhang,

Wei

et al. 2024

ACS Nano

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Lasso peptides, natural biological microcins composed of small molecules, have demonstrated efficient bactericidal activity. However, a single lasso peptide is characterized by a narrow and targeted bactericidal spectrum. In this study, a chitosan (CN) derivative-based polymer nanomaterial incorporating three lasso peptides (MccY, MccJ25, and Klebsidin) was designed and synthesized to broaden its antimicrobial spectrum. To enhance resistance to acid and alkali conditions, arginine was appended to the terminus of conjugates, resulting in Chitosan-Lasso-Peptides-Arg (CN-LPs-Arg), and the nanomaterial biocompatibility and bactericidal activity were characterized. Chemical stability test results demonstrate that CN-LPs-Arg effectively buffered the acid−base effect of the compound. Notably, CN-LPs-Arg extended the antimicrobial spectrum of Gram-negative and Grampositive strains including Klebsiella, Salmonella, and Staphylococcus (MIC = 0.01−1.0 μM). CN-LPs-Arg exerts its destructive effects on bacteria via a series of mechanisms; it adheres to and then penetrates the membrane, causes rupture, and leads to bacterial death. Transcriptomic data revealed that CN-LPs-Arg produced a distinct inhibitory effect on ribosomal protein subunits synthesis pathways and membrane metabolic inhibition. Furthermore, CN-LPs-Arg was nontoxic to cells and exhibited excellent biocompatibility. CN-LPs-Arg reduced bacterial burden in organs and the levels of inflammatory factors IL-6, IL-8, and TNF-α in tissues of mice with acute bacterial infections. Furthermore, it promoted the recovery of Klebsiellainfected C57BL/6 mice, demonstrating a favorable therapeutic effect in vivo. The multilasso peptide-based synergistic nanocomposite of CN-LPs-Arg exhibited high stability as a broad-spectrum antimicrobial agent with potential for combined antibacterial therapy and utilization in the fields of food, biomedicine, and public health.

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Efficient Synthetic Access to Novel Indolo[2,3-b]Quinoxaline-based Heterocycles

Cited by 4 publications

References 33 publications

Novel synthesis of some heterocycles and their molluscicidal activity against the destructive land snail, Theba pisana

Novel synthesis of some heterocycles and their molluscicidal activity against the destructive land snail, Theba pisana

Biological activities of novel 2-pyrazolin-5-one derivatives and their toxicity on certain pests infesting field crops in laboratory conditions

Multi-Lasso Peptide-Based Synergistic Nanocomposite: A High-Stability, Broad-Spectrum Antimicrobial Agent with Potential for Combined Antibacterial Therapy

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