Multipath channels continue to present challenges in wireless communication for both 5G and 6G networks. A multipath channel is a phenomenon in wireless communications where signals traverse from the sender to the receiver along various paths. This end occurs due to the reflection, diffraction, and refraction of signals of various objects and structures in the environment. Such pathways can cause symbol interference in the transmitted signal, leading to communication issues. To this end, our paper proposes the integration of three algorithms: teaching-learning-based optimization (TLBO), particle swarm optimization (PSO), and artificial neural networks (ANN). This combination effectively analyzes and stabilizes the transmission channel, minimizing symbol interference. We have developed, simulated, and evaluated this hybrid approach for multipath fading channels. We apply it to various coding schemes, including tail-biting convolutional code, turbo codes, low-density parity-check, and polar code. Additionally, we have explored various decoding methods such as Viterbi, maximum logarithmic maximum a posteriori, minimum sum, and cyclic redundancy check soft cancellation list. Our study encompasses new channel equalization schemes and coding gains derived from simulations and mathematical analysis. Our proposed method significantly enhances channel equalization, reducing interference and improving error correction in wireless communication systems.