Lack of knowledge of latex harvesting techniques from Hevea brasiliensis clones results in a high rate of unproductive trees and a drop in rubber production. In order to improve these techniques and to determine the stimulation regime allowing the clones to express their production potential, a study was undertaken for 6 years in the south-eastern part of the Ivory Coast. It focused on clones of Hevea brasiliensis with active metabolism (IRCA 111 and IRCA 130) planted at a density of 510 trees / ha (7 m X 2.80 m), bled in a descending semi-spiral every 4 days (S / 2 d4) with a day of rest (Sunday) and stimulated with Ethephon at 2.5% at frequencies varying from 0 to 26 stimulations per year. The parameters measured were rubber production, isodiametric trunk growth, physiological profile, sensitivity to dry notching and tree metabolic index. The results of this experiment showed that beyond six and four annual stimulations respectively for the clones IRCA 111 and IRCA 130, any increase in the frequency of stimulation becomes very stressful for the tree, leading not only to a drop in production. Of rubber, but also that of the growth in thickness. Also, the stimulation had a detrimental effect on the sugar content of the IRCA 130 clone. It had no significant effect on the inorganic phosphorus content of the clones studied, but on the other hand it caused a decrease. Their content of thiol compounds. As for the sensitivity to dry notch, it is noticeable in these two clones of the rapid metabolic activity class. However, the clones displayed a good physiological profile with optimal stimulation.