Efflux pumps potential drug targets to circumvent drug Resistance – Multi drug efflux pumps of Helicobacter pylori

Customizing delivery nano-vehicles for precise brain tumor therapy

“…As was mentioned previously, the transport of medicines across the brain capillary endothelial cells is exceedingly challenging because of the strict properties of the BBB provided by the tight junction [ 49 ]. Figure 5 illustrates how the existence of efflux pumps further complicates the already challenging task of medication distribution [ 53 ]. Near the cell surface, or luminal side, of BBB endothelial cells.…”

Analysis of antibiotic resistance genes in pig feces during the weaning transition using whole metagenome shotgun sequencing

“…Multidrug and antimicrobial extrusion protein (MATE), ATP Binding cassette transporter (ABC) and Small multidrug resistance (SMR) [25]. All bacteria contain several efflux pumps, which extrude not only antibiotic substrates but also non-antibiotic substrates such as heavy metals, dyes, detergents and organic solvents [26][27][28].…”

Modifications, biological origin and antibacterial activity of naphthalenoid ansamycins

“…The chameleonic nature of naphthalenoid ansamycins is important not only for transportation and binding with the target but can be essential from a bacteria resistance viewpoint, via increased/decreased affinity to efflux pump systems. 44,63,64 The zwitterionization phenomenon for naphthalenoid ansamycins as rifamycins have also impact on their polymorphism in the crystal state, which is a very important problem discussed at potential pharmaceutical applications of this group of macrolactams in the treatment of bacterial infections (including tuberculosis). 52,65–69…”