Efflux transporters in cancer resistance: Molecular and functional characterization of breast cancer resistance protein

An, Guohua; Morris, Marilyn E.

doi:10.1016/b978-0-12-816434-1.00003-6

Cited by 5 publications

(4 citation statements)

References 195 publications

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“…In the quantification of substrate transport, we suggest the use of fluorescent substrates first because of the easiness of the quantification of the fluorescence strength. However, it should be noted that rhodamine 123 and Hoechst 33,324 are not highly specific to P -gp and BCRP [ 38 , 39 ], respectively. We therefore recommend the confirmation of the results obtained in fluorescence quantification using more specific substrates: digoxin for P -gp, dantrolene and SASP for BCRP.…”

Section: Resultsmentioning

confidence: 99%

Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system

Nakayama-Kitamura

Shigemoto-Mogami

Toyoda³

et al. 2023

Regenerative Therapy

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Section: Resultsmentioning

confidence: 99%

Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system

Nakayama-Kitamura

Shigemoto-Mogami

Toyoda³

et al. 2023

Regenerative Therapy

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“…One of its major compounds, the 5,3′,5′-trihydroxy-3,6,7,4′-tetramethoxyflavone, strongly suppressed the breast cancer resistance protein (BCRP/ABCG2) [ 346 ] which belongs to the family of ATP-binding cassette proteins. BCRP mediates multidrug resistance and promotes an efflux of such potent drugs, such as methotrexate, irinotecan, topotecan, sorafenib, gefitinib, and doxorubicin, from cancer cells [ 347 ].…”

Section: Plants From Different Continents Used In Ethnomedicine For T...mentioning

confidence: 99%

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

et al. 2022

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Traditional herbal medicine (THM) is a “core” from which modern medicine has evolved over time. Besides this, one third of people worldwide have no access to modern medicine and rely only on traditional medicine. To date, drugs of plant origin, or their derivates (paclitaxel, vinblastine, vincristine, vinorelbine, etoposide, camptothecin, topotecan, irinotecan, and omacetaxine), are very important in the therapy of malignancies and they are included in most chemotherapeutic regimes. To date, 391,000 plant and 14,000 mushroom species exist. Their medical and biochemical capabilities have not been studied in detail. In this review, we systematized the information about plants and mushrooms, as well as their active compounds with antitumor properties. Plants and mushrooms are divided based on the regions where they are used in ethnomedicine to treat malignancies. The majority of their active compounds with antineoplastic properties and mechanisms of action are described. Furthermore, on the basis of the available information, we divided them into two priority groups for research and for their potential of use in antitumor therapy. As there are many prerequisites and some examples how THM helps and strengthens modern medicine, finally, we discuss the positive points of THM and the management required to transform and integrate THM into the modern medicine practice.

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“…Structurally, BCRP2 is a-72 kDa protein comprised of a transmembrane domain (TMD) of 6 alfa-helices and a nucleotide binding domain (NBD) at the N-terminal where an ATP is hydrolyzed into ADP during transport. To be functional, two BCRP2 monomers associate in a homodimer forming a transmembrane channel that allows the efflux of a large spectrum of xenotoxic substrates, including different types of mycotoxins and their conjugates [ 8 , 66 , 67 , 68 ] ( Figure 2 d). During lactation, BCRP2 is upregulated with a concomitant increase in the yield of milk and excretion of mycotoxins [ 8 , 69 , 70 , 71 , 72 , 73 , 74 ].…”

Section: Physiological Mechanisms Of Afm1 Secretion Into Breast Milkmentioning

confidence: 99%

“…As the multidrug and xenobiotic efflux transporters are beyond the scope of this review, for more information on the structural diversity, classification, and molecular functioning, the readers are referred to relevant literature reviews, e.g., refs. [ 67 , 68 , 81 , 82 , 83 ].…”

Section: Physiological Mechanisms Of Afm1 Secretion Into Breast Milkmentioning

confidence: 99%

Human Breast Milk Contamination with Aflatoxins, Impact on Children’s Health, and Possible Control Means: A Review

Benkerroum¹,

Ismail

2022

IJERPH

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Aflatoxins are natural toxicants produced mainly by species of the Aspergillus genus, which contaminate virtually all feeds and foods. Apart from their deleterious health effects on humans and animals, they can be secreted unmodified or carried over into the milk of lactating females, thereby posing health risks to suckling babies. Aflatoxin M1 (AFM1) is the major and most toxic aflatoxin type after aflatoxin B1 (AFB1). It contaminates human breast milk upon direct ingestion from dairy products or by carry-over from the parent molecule (AFB1), which is hydroxylated in the liver and possibly in the mammary glands by cytochrome oxidase enzymes and then excreted into breast milk as AFM1 during lactation via the mammary alveolar epithelial cells. This puts suckling infants and children fed on this milk at a high risk, especially that their detoxifying activities are still weak at this age essentially due to immature liver as the main organ responsible for the detoxification of xenobiotics. The occurrence of AFM1 at toxic levels in human breast milk and associated health conditions in nursing children is well documented, with developing countries being the most affected. Different studies have demonstrated that contamination of human breast milk with AFM1 represents a real public health issue, which should be promptly and properly addressed to reduce its incidence. To this end, different actions have been suggested, including a wider and proper implementation of regulatory measures, not only for breast milk but also for foods and feeds as the upstream sources for breast milk contamination with AFM1. The promotion of awareness of lactating mothers through the organization of training sessions and mass media disclosures before and after parturition is of a paramount importance for the success of any action. This is especially relevant that there are no possible control measures to ensure compliance of lactating mothers to specific regulatory measures, which can yet be appropriate for the expansion of breast milk banks in industrialized countries and emergence of breast milk sellers. This review attempted to revisit the public health issues raised by mother milk contamination with AFM1, which remains undermined despite the numerous relevant publications highlighting the needs to tackle its incidence as a protective measure for the children physical and mental health.

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Efflux transporters in cancer resistance: Molecular and functional characterization of breast cancer resistance protein

Cited by 5 publications

References 195 publications

Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system

Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

Human Breast Milk Contamination with Aflatoxins, Impact on Children’s Health, and Possible Control Means: A Review

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