1994
DOI: 10.1007/bf01776488
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Effort syndrome: Hyperventilation and reduction of anaerobic threshold

Abstract: Effort syndrome is an entity in danger of being subsumed into "chronic fatigue syndrome" and lost to sight. Its distinctive feature is the reduction of the anaerobic threshold for work by depletion of the body's alkaline buffering systems through hyperventilation. This article describes the history and clinical features of effort syndrome and reports a study in which capnography is used to identify the anaerobic threshold by registering the respiratory response to the onset of metabolic acidosis. The patients'… Show more

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Cited by 14 publications
(5 citation statements)
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“…Alkalosis in skeletal muscles may result in a compensated acidosis in the blood, precipitating hyperventilation [91]. This theory has been proposed from evidence of hyperventilation in patients with ME/CFS [92] and an inverse association between skeletal muscle pH and cerebral blood flow [91]. Compared to sedentary controls, ME/CFS patients have higher skeletal muscle pH at rest [93] and at recovery after exercise [93].…”
Section: Discussionmentioning
confidence: 99%
“…Alkalosis in skeletal muscles may result in a compensated acidosis in the blood, precipitating hyperventilation [91]. This theory has been proposed from evidence of hyperventilation in patients with ME/CFS [92] and an inverse association between skeletal muscle pH and cerebral blood flow [91]. Compared to sedentary controls, ME/CFS patients have higher skeletal muscle pH at rest [93] and at recovery after exercise [93].…”
Section: Discussionmentioning
confidence: 99%
“…With the development of chronic hyperventilation, the pH compensation will partly offset the normal ‘CO 2 brake’ on hyperventilation , perhaps making hyperventilation self‐sustaining also when the original stressor producing the hyperventilation has disappeared . The mask treatment reduced the metabolic pH compensation (signified by the decrease in negative SBE), but this did not by itself seem to lead to a ‘virtuous circle’ of reduced hyperventilation, rather this seemed to be dependent on the continual use of the mask.…”
Section: Discussionmentioning
confidence: 99%
“…It is not fully known whether such an increase in ventilatory drive and/or decrease of the CO 2 set point are genetic or acquired traits, although a theory has been proposed that a period of hyperventilation (brought on by for example an extended period of anxiety or physical pain) can lower the CO 2 set point permanently, in effect making hyperventilation chronic .…”
Section: Introductionmentioning
confidence: 99%
“…However, if the loss in CO 2 increases due to a greater severity of chronic hyperventilation, loss of bicarbonate will result in a progressive lowering of the CO 2 set point at which acid-base balance is re-established. Over time, the loss of bicarbonate in the extracellular fluids critically reduces the alkaline buffering system below levels required to maintain everyday physical activities [Nixon, 1994]. Under these conditions, physical effort related to work, even that of light duty office tasks, compromises the body's ability to buffer the buildup of metabolic byproducts in muscle tissue.…”
Section: A Hyperventilation Theorymentioning
confidence: 99%