2012
DOI: 10.4067/s0716-10182012000100013
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Eficacia de nifurtimox para el tratamiento de pacientes con enfermedad de Chagas crónica

Abstract: Background: Most Chagas patients belong to the chronic indeterminate stage, in which pharmacological treatment has an inconclusive outcome. Objective: To evaluate the effi cacy of nifurtimox treatment in chronic asymptomatic Trypanosoma cruzi infection. Methods: We performed a systematic review and meta-analysis of electronically published literature, with no language, type of study, age or gender restrictions, until September 2010. Studies of chronic asymptomatic Chagas disease patients treated exclusively wi… Show more

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Cited by 17 publications
(14 citation statements)
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“…De estas opciones terapéuticas, la que se usa con mayor frecuencia es benznidazol, ya que se ha demostrado que es mejor tolerado por los pacientes (14)(15)(16) .…”
Section: Manejo Actual De La Tripanosomiasis Americanaunclassified
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“…De estas opciones terapéuticas, la que se usa con mayor frecuencia es benznidazol, ya que se ha demostrado que es mejor tolerado por los pacientes (14)(15)(16) .…”
Section: Manejo Actual De La Tripanosomiasis Americanaunclassified
“…En la mayoría de los casos la detección de la enfermedad tiene lugar en las fases crónicas, cuando las secuelas ya mencionadas comienzan a ser más evidentes y el tratamiento antiparasitario parece no ser tan efectivo (14,22) .…”
Section: Manejo Actual De La Tripanosomiasis Americanaunclassified
“…Numerous other studies followed, but they were conducted under highly variable conditions and according to protocols so different that it is very difficult to make comparisons among them. According to the most recent meta-analyses of these studies, the results are contradictory and far too inadequate in every way for recommending a treatment for all chronic Chagas disease patients [11,20,27]. According to one of these studies, the parasitological cure rate of patients 15-70 years old in whom treatment was delayed was a mere 5.9% [13].…”
Section: Long Expensive and Hard-to-obtain Treatmentsmentioning
confidence: 99%
“…De nombreuses autres études ont suivi, dans des conditions et avec des protocoles si différents qu'il est très difficile de les comparer dans leur ensemble. Les méta-analyses les plus récentes font état, à leur sujet, de résultats contradictoires et de toute manière beaucoup trop insuffisants pour recommander un traitement de tous les chagasiques chroniques [11,20,27]. L'une d'entre elles évalue même à 5,9 % seulement le taux de guérison parasitologique des patients âgés de 15 à 70 ans traités tardivement [13].…”
Section: Traitements Longs Coûteux Et Difficilement Accessiblesunclassified