Eficacy of Cryotherapy in the Prevention of Oral Mucosistis in Adult Patients with Chemotherapy

González, Ángel Luis; García-Quintanilla, Marta; Guerrero-Agenjo, Carmen María; Tendero, Jaime López; Guisado-Requena, Isabel María; Rabanales-Sotos, Joseba

doi:10.3390/ijerph18030994

Cited by 9 publications

(9 citation statements)

References 24 publications

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“…Thus, rhIL-11 has the potential to reduce chemotherapy-related OM. Moreover, epithelial cells contain the colony-stimulating factor receptor, which is bound by rhIL-11 to stimulate the migration and proliferation of epithelial cells and promote the growth of keratinocytes and fibroblasts [7]. Thus, rhIL-11 may promote the proliferation and maturation of endothelial cells to accelerate the healing of OM caused by chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it has a negative impact on the delivery of optimal cancer treatments [5,6]. For these reasons, it is extremely necessary to treat OM, with the goal of preventing or reducing the severity of lesions and managing the associated symptoms, thereby allowing the continuation of cancer therapy [1,7,8].…”

Section: Introductionmentioning

confidence: 99%

“…It has been widely used for treating bone marrow suppression caused by chemotherapy and radiotherapy since its discovery in a mouse lungconditioned medium in 1977 [12]. Recent studies have found that rhIL-11 can directly promote the proliferation and migration of endothelial cells, enhance the activity of other angiogenic factors, and promote healing of the mucosa [7,13]. Currently, there are a few articles focusing on the value of rhIL-11 in OM, and there is no strong evidence that rhIL-11 can be recommended for the prevention and treatment of OM.…”

Section: Introductionmentioning

confidence: 99%

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A prospective interventional study of recombinant human interleukin-11 mouthwash in chemotherapy-induced oral mucositis

Wei

Dong

2022

BMC Oral Health

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Background This prospective interventional study aimed to evaluate and analyse the efficacy of rhIL-11 mouthwash compared to Kangfuxin fluid in treatment and blank control in prevention of oral mucositis (OM) in patients receiving chemotherapy. Materials and Methods In total, 50 patients in the treatment group and 62 patients in the prevention group were included. Subsequently, each group was divided into an experimental group and a control group. In the treatment group, the experimental patients received recombinant human interleukin-11 (rhIL-11) mouthwash, whereas the control group received Kangfuxin fluid. In the prevention group, experimental patients still received rhIL-11 mouthwash based on routine oral care, whereas the control group only received routine oral care. Meanwhile, we observed and recorded the efficacy in the treatment group, and the occurrence and grades of OM in the prevention group. Results Through statistical analysis, the results showed that on the seventh day of treatment, the experimental group showed more improvement compared to the control group, and it was statistically significant (p = 0.032). The average healing time in the experimental group (3.59 ± 1.927 days) was shorter than that in the control group (4.96 ± 2.421 days; p = 0.031). In the prevention group, we observed the incidence of oral mucositis. No significant differences were found in the occurrence and grades of OM in the experimental and control groups (p = 0.175). Conclusion Our preliminary results indicate that rhIL-11 mouthwash may be a superior option to treat OM, especially in severe cases, compared to Kangfuxin fluid. However, there is no advantage in prevention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A prospective interventional study of recombinant human interleukin-11 mouthwash in chemotherapy-induced oral mucositis

Wei

Dong

2022

BMC Oral Health

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“…López-González et al (2021) [77] proved the efficacy of oral cryotherapy for preventing and treating OM. This evidence was also found in several clinical practice guidelines, highlighting its best utility in the prevention of OM in patients treated with CT.…”

Section: Othersmentioning

confidence: 99%

A Narrative Review about Nutritional Management and Prevention of Oral Mucositis in Haematology and Oncology Cancer Patients Undergoing Antineoplastic Treatments

García-Gozalbo

Cabañas-Alite

2021

Nutrients

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Cancer is a prevalent disease worldwide, and treatments such as radiotherapy and chemotherapy sometimes lead to adverse events. Oral mucositis is one of the most disabling adverse events, and clinical guidelines do not take into account nutritional interventions. The primary endpoint was to gather the evidence about the efficacy of nutritional interventions in the prevention and/or treatment of antineoplastic-induced oral mucositis in oncological patients. A bibliographic review was carried out in the PubMed data base by combining MeSH terms with Boolean operators. Articles were selected based on inclusion and exclusion criteria; 50 final articles were found. Although further evidence is needed, glutamine, honey, and vitamins appear to be good therapeutic options. The rest of the compounds presented controversial or insufficient results, making it difficult to draw conclusions over their utilization as prevention or treatment options. Little evidence is reported about oral mucositis nutritional interventions in spite of them being attainable and affordable compounds. Scarce evidence is shown in paediatric patients compared with adults. Developing higher quality studies and combinations with the compounds researched is necessary for creating a stronger body of evidence.

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“…The World Health Organization (WHO) scale evaluates OM as having 5 grades, from grade 0-normal mucosa, to grade 4 with deep lesions, when feeding the patient is not possible, making parenteral support necessary [28].…”

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confidence: 99%

Oral Mucositis Induced by Chemoradiotherapy in Head and Neck Cancer—A Short Review about the Therapeutic Management and the Benefits of Bee Honey

et al. 2022

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Background and Objectives: Oral mucositis, a severe non-hematological complication, can be induced by chemoradiotherapy. It is associated with severe local dysfunction, severely affecting the patient’s quality of life; it increases the risk of oral infections and interrupts oncological treatment, thus prolonging the duration and cost of hospitalization. Besides all of the agents used in the prevention and treatment of oral mucositis induced by oncological treatment, can there be found an easier one to administer, with an effective preparation, high addressability, both for adults and paediatric patients, without side effects, and at the same time cheap and easy to purchase? The aim of the present paper is to demonstrate the existence of this product, which is available to everyone, having multiple benefits. Materials and Methods: For the purpose of writing this article, materials were searched in electronic databases in between 2019 and 2021, taking into consideration papers where authors have demonstrated the effectiveness of this product through its topical or systemic use. Results: Numerous studies have highlighted the benefits of honey on oral mucositis. Through its analgesic, anti-inflammatory, anti-cancerous and antibacterial action, honey has proved to have a major impact on the patient’s quality of life and nutritional status by promoting tissue epithelialization and healing of the chemoradiotherapy-induced lesions. Conclusions: Superior to many natural agents, bee honey can be successfully used in both preventing and treating oral mucositis. There are currently numerous studies supporting and recommending the use of bee honey in the management of this oncological toxicity.

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Eficacy of Cryotherapy in the Prevention of Oral Mucosistis in Adult Patients with Chemotherapy

Cited by 9 publications

References 24 publications

A prospective interventional study of recombinant human interleukin-11 mouthwash in chemotherapy-induced oral mucositis

A prospective interventional study of recombinant human interleukin-11 mouthwash in chemotherapy-induced oral mucositis

A Narrative Review about Nutritional Management and Prevention of Oral Mucositis in Haematology and Oncology Cancer Patients Undergoing Antineoplastic Treatments

Oral Mucositis Induced by Chemoradiotherapy in Head and Neck Cancer—A Short Review about the Therapeutic Management and the Benefits of Bee Honey

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