EFLDO induces apoptosis in hepatic cancer cells by caspase activation in vitro and suppresses tumor growth in vivo

Qu, Yanbo; Liao, Zhi‐Xin; Liu, Chao; Wang, Xinzhu; Zhang, Jing

doi:10.1016/j.biopha.2018.02.004

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…Qu et al studied the apoptogenic effect of EFLDO (ent‐3α‐formylabieta‐8(14), 13(15)‐dien‐16,12β‐olide), extracted from the Euphorbia lunulata Bge, in the HepG2 cell line. Activation of caspases‐3, ‐8, and ‐9 played an important role in EFLDO‐induced apoptosis in‐vitro at a concentration of 25 and 50 µM for 24 and 48 h 55 . Novel antitumor compound D13 obtained from natural saponin Albiziabioside A has reported a strong inhibitory activity against HCT116 cells with IC 50 values of 5.19 µM and induced caspase‐dependent apoptosis after treatment for 73 h 56 .…”

Section: Role Of Phytochemicals As Caspase Inducers: Natural Semisynt...mentioning

confidence: 99%

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Allani,

Akhilesh,

Tiwari

2024

Cell Biochemistry & Function

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Apoptosis is the cell's natural intrinsic regulatory mechanism of normal cells for programmed cell death, which plays an important role in cancer as a classical mechanism of tumor cell death causing minimal inflammation without causing damage to other cells in the vicinity. Induction of apoptosis by activation of caspases is one of the primary targets for cancer treatment. Over the years, a diverse range of natural, synthetic, and semisynthetic compounds and their derivatives have been investigated for their caspase‐mediated apoptosis‐induced anticancer activities. The review aims to compile the preclinical evidence and highlight the critical mechanistic pathways related to caspase‐induced cell apoptosis in cancer treatment. The focus is placed on the key components of the mechanisms, including their chemical nature, and specific attention is given to phytochemicals derived from natural sources and synthetic and semisynthetic compounds. 180+ compounds from the past two decades with potential as anticancer agents are discussed in this review article. By summarizing the current knowledge and advancements in this field, this review provides a comprehensive overview of potential therapeutic strategies targeting apoptosis in cancer cells. The findings presented herein contribute to the ongoing efforts to combat cancer and stimulate further research into the development of effective and targeted anticancer therapies.

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Section: Role Of Phytochemicals As Caspase Inducers: Natural Semisynt...mentioning

confidence: 99%

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Allani,

Akhilesh,

Tiwari

2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…Furthermore, 16 inhibited HepG2 tumor growth in xenograft mouse models with the proliferation characteristics (Ki67 index) being significantly suppressed. 88 Fischernolide B ( 278 ) showed significant cytotoxicity and induced apoptosis of MCF-7 and Bel-7402 cell lines by the activation of caspases-3 and 7. 77 Euphorkanlide A ( 778 ) displayed significant cytotoxicity against a panel of cancer cell lines and induced the generation of reactive oxygen species (ROS), resulting in cell cycle arrest and cell apoptosis in HCT-15/5-FU cells.…”

Section: Biological Activitiesmentioning

confidence: 99%

Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)

et al. 2022

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“…At present, it is considered that the pathogenesis of hepatic cancer is a complex process of multi-factor and multi-step. Epidemiological and experimental data showed that many factors, consisting of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, aflatoxin, drinking water pollution, alcohol, cirrhosis, sex hormones, nitrosamines, trace elements and so on, are related to the incidence of hepatic malignant tumors (3). Individualized comprehensive therapy according to different stages of hepatic carcinoma is the key to improving the curative effect.…”

Section: Introductionmentioning

confidence: 99%

Correlation of insulin‑resistance with blood fat and glucose in elder patients after surgery for hepatic carcinoma

et al. 2018

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The present study was designed to analyze variations in blood fat, blood glucose and insulin-resistance in elder patients following surgery for hepatic carcinoma. It also investigated the correlation of insulin with the level of serum leptin and blood fat. A total of 80 patients with primary hepatic cancer who were admitted to The First Hospital of Lanzhou University for treatment between October 2014 and June 2016 were enrolled in the study. At the 1-year follow-up, the patients were divided into two groups based on their recurrence of hepatic cancer after surgery. The levels of serum leptin were detected prior to, one month and one year after surgery; the changes in blood fat, body mass index (BMI), waistline and hipline were measured at one year after surgery; alterations in the fasting blood glucose and blood glucose were measured at 2 h after meal. The fasting insulin (FINS) level and homeostasis model assessment-insulin resistance (HOMA-IR) index were also measured. Correlations between serum leptin and total cholesterol, FINS and fasting blood glucose were analyzed. In the recurrence group, the levels of serum leptin and FINS level were significantly reduced, while waistline and hipline were increased, compared with the non-recurrence group (P<0.05). The BMI and fasting blood glucose in the recurrence group was significantly elevated in comparison with the non-recurrence group (P<0.05). The HOMA-IR index was significantly increased in the recurrence group compared with the non-recurrence group (P<0.05). These results indicated that following surgery for hepatic cancer, the level of serum leptin in patients with recurrence was decreased with an increase in susceptibility to abnormal metabolism of blood fat and glucose. In addition, the serum leptin was negatively correlated with the total cholesterol level and fasting blood glucose and positively correlated with the FINS level in patients. It was concluded that leptin levels decreased in patients with postoperative recurrence, as well as the accumulation of visceral adipose tissue and the development of abnormal blood glucose metabolism was observed.

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EFLDO induces apoptosis in hepatic cancer cells by caspase activation in vitro and suppresses tumor growth in vivo

Cited by 6 publications

References 43 publications

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications

Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)

Correlation of insulin‑resistance with blood fat and glucose in elder patients after surgery for hepatic carcinoma

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