EGCG regulates fatty acid metabolism of high-fat diet-fed mice in association with enrichment of gut Akkermansia muciniphila

Green Tea and Its Relation to Human Gut Microbiome

“…Whether these correlations have or do not have biological significance remains unclear. Similar results have been found in other studies, where Firmicutes was reduced by green tea polyphenols or by EGCG specifically [ 21 , 61 , 62 ].…”

“…Several other studies carried out in mice found how green tea extracts favored the growth of Akkermansia, a genus known to degrade mucin [ 20 , 21 ]. EGCG was found to favor the growth of Akkermansia though, at the same time, this catechin reduced the abundance of the phyla Firmicutes and the overall alpha diversity of the community.…”

“…EGCG was found to favor the growth of Akkermansia though, at the same time, this catechin reduced the abundance of the phyla Firmicutes and the overall alpha diversity of the community. Alpha diversity refers to a measure of microbiome diversity in a single sample [ 21 ]. This was explained by the antibacterial activity of EGCG [ 21 ].…”

“…Alpha diversity refers to a measure of microbiome diversity in a single sample [ 21 ]. This was explained by the antibacterial activity of EGCG [ 21 ]. Akkermansia has been given some importance due to its apparent correlation with lipid metabolism and obesity, being even considered as an anti-obesogenic bacterium [ 22 , 23 , 24 ].…”

“…Green tea and EGCG have been reported to increase the relative abundance of Akkermansia muciniphila in mice fed with high-fat diet [ 21 , 63 ]. However, this microbe has also been reported to decrease after supplementing a normal diet with EGCG [ 58 ], existing therefore certain discrepancies.…”