EGEA Collection: A Biobank Devoted to Asthma and Asthma-related Phenotypes

Nadif, Rachel; Moual, Nicole Le; Siroux, Valérie

doi:10.5334/ojb.24

Cited by 8 publications

(10 citation statements)

References 10 publications

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“…The protocol and descriptive characteristics have been described previously [20,21]. The EGEA collection is certified ISO 9001 and referenced in the Biobank network [22].…”

Section: Methodsmentioning

confidence: 99%

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Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

et al. 2017

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Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06-1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41-0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07-1.65), poor asthma control (1.30, 1.02-1.66) and poor lung function (1.34, 1.04-1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.

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“…The protocol and descriptive characteristics have been described previously [20,21]. The EGEA collection is certified ISO 9001 and referenced in the Biobank network [22].…”

Section: Methodsmentioning

confidence: 99%

“…Exhaled breath condensate (EBC) was collected using an RTube according a standardised method as previously described [22]. Briefly, the RTube was rinsed with deionised water and dried thoroughly.…”

Section: Biomarkers Of Damagementioning

confidence: 99%

Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

et al. 2017

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“…The protocol and descriptive characteristics have been described previously [13,14], and inclusion criteria used to define asthmatic cases and controls are described in the supplementary material. The EGEA collection is certified ISO 9001 [15]. Ethical approval was obtained from the relevant institutional review board committees (Cochin Port-Royal Hospital and Necker-Enfants Malades Hospital, Paris, France).…”

Section: Study Populationmentioning

confidence: 99%

Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study

et al. 2018

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Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter ≤10 and ≤2.5 µm (PM and PM), road traffic, and ozone (O) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence.The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00-1.18) per 5000 vehicles per day), with O exposure (aOR 2.04 (95% CI 1.27-3.29) per 10 µg·m) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06-2.12) per 1 pg·mL). Among participants without asthma, exhaled 8-iso concentration increased with PM exposure (adjusted (a)β 0.23 (95% CI 0.005-0.46) per 5 µg·m), and decreased with O and O exposures (aβ -0.20 (95% CI -0.39- -0.01) and aβ -0.52 (95% CI -0.77- -0.26) per 10 µg·m, respectively).Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.

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“…An aliquot of the same serum pool was run by duplicate in each plate. In order to minimize interplate variability, values of leptin concentration were divided by the pool result of the same plate and expressed as ratios .…”

Section: Methodsmentioning

confidence: 99%

Role of Leptin in the Association Between Body Adiposity and Persistent Asthma: A Longitudinal Study

Leynaert

Dumas

et al. 2019

Obesity

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Objective: Obesity is a likely risk factor for asthma. However, underlying mechanisms by which obesity affects asthma activity remain poorly understood. This study aimed to investigate the role of leptin, an adipocyte-derived proinflammatory protein, as a mediator in the association between body adiposity (assessed using BMI, waist circumference, and body fat percentage) and persistent asthma. Methods: A causal approach to mediation analysis was used to disentangle total and direct effects and the indirect effect mediated by leptin, using data from the French prospective French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) (baseline: 2003-2007; follow-up: 2011-2013; mean followup time: 7 years). A total of 331 participants with current asthma at baseline were included. Results: Per 1-SD increment in BMI, waist circumference, and body fat percentage, the adjusted odds ratios of the total effect were 1.59 (95% CI: 0.95-2.97), 2.06 (1.06-4.00), and 3.25 (1.01-9.41), respectively; the odds ratios of the indirect effect mediated by leptin were 1.68 (1.09-2.46), 1.55 (0.99-2.57), and 1.99 (0.94-4.83), respectively. Conclusions: Leptin partly (> 60%) mediated the association between high body adiposity and persistent asthma over time. Using a newly developed analytic approach, this longitudinal study brought new insight into one mechanism by which obesity may affect asthma activity.

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EGEA Collection: A Biobank Devoted to Asthma and Asthma-related Phenotypes

Cited by 8 publications

References 10 publications

Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study

Role of Leptin in the Association Between Body Adiposity and Persistent Asthma: A Longitudinal Study

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