EGF-functionalized single-walled carbon nanotubes for targeting delivery of etoposide

Chen, Cheng; Xie, Xiaoqing; Zhou, Qian; Zhang, Fengyi; Wang, Qiaoling; Liu, Yaqing; Zou, Yina; Tao, Qing; Ji, Xuemei; Yu, Shu‐Qin

doi:10.1088/0957-4484/23/4/045104

Cited by 39 publications

(19 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is propitious for S-D1@L-D2 NPs to transport through blood vessels and retain in circulation for long periods, as well as internalize by means of endocytosis. 25,37,38 Its inner smaller…”

Section: Physical and Chemical Characterizationmentioning

confidence: 99%

“…Therefore, the intracellular precision release of NDDS-loaded P-gp substrates is still a demanding issue. There were a variety of drug delivery techniques to reduce the efflux associated with P-gp, such as using biological materials with interference of P-gp function, like vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS), and adding P-gp inhibitor, [24][25][26][27] like verapamil. Recently, we have reported that a type of NPs can carry a drug as the P-gp substrate into the nucleus and release it in the nucleus of MDR cell.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance

Zhang

Kong

Jie

et al. 2017

IJN

View full text Add to dashboard Cite

Combination chemotherapy in clinical practice has been generally accepted as a feasible strategy for overcoming multidrug resistance (MDR). Here, we designed and successfully prepared a co-delivery system named S-D1@L-D2 NPs, where denoted some smaller nanoparticles (NPs) carrying a drug doxorubicin (DOX) were loaded into a larger NP containing another drug (vincristine [VCR]) via water-in-oil-in-water double-emulsion solvent diffusion-evaporation method. Chitosan-alginate nanoparticles carrying DOX (CS-ALG-DOX NPs) with a smaller diameter of about 20 nm formed S-D1 NPs; vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate-modified poly(lactic-co-glycolic acid) nanoparticles carrying VCR (TPGS-PLGA-VCR NPs) with a larger diameter of about 200 nm constituted L-D2 NPs. Some CS-ALG-DOX NPs loaded into TPGS-PLGA-VCR NPs formed CS-ALG-DOX@TPGS-PLGA-VCR NPs. Under the acidic environment of cytosol and endosome or lysosome in MDR cell, CS-ALG-DOX@TPGS-PLGA-VCR NPs released VCR and CS-ALG-DOX NPs. VCR could arrest cell cycles at metaphase by inhibiting microtubule polymerization in the cytoplasm. After CS-ALG-DOX NPs escaped from endosome, they entered the nucleus through the nuclear pore and released DOX in the intra-nuclear alkaline environment, which interacted with DNA to stop the replication of MDR cells. These results indicated that S-D1@L-D2 NPs was a co-delivery system of intracellular precision release loaded drugs with pH-sensitive characteristics. S-D1@L-D2 NPs could obviously enhance the in vitro cytotoxicity and the in vivo anticancer efficiency of co-delivery drugs, while reducing their adverse effects. Overall, S-D1@L-D2 NPs can be considered an innovative platform for the co-delivery drugs of clinical combination chemotherapy for the treatment of MDR tumor.

show abstract

Section: Physical and Chemical Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance

Zhang

Kong

Jie

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…61 Its drug loading capacity was 25−27%. The cell death induced by the EGF/CHI/SWNT−COOHs/ ETO was as much as 2.7 times that due to ETO alone.…”

Section: Organo-modified Cntsmentioning

confidence: 99%

Modification Strategies for Carbon Nanotubes as a Drug Delivery System

Liu

2013

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

Carbon nanotubes (CNTs) are extensively explored in materials science due to their unique structure and consequent mystical properties. CNTs are enjoying increasing popularity as building blocks for novel drug delivery systems as well as for bioimaging and biosensing. The recent strategies to functionalize CNTs have resulted in the generation of biocompatible and water-soluble CNTs that are well suited for high treatment efficacy and minimum side effects for future cancer therapies with low drug doses. This review covers the latest advances in the strategies for the modification of CNTs (with inorganic nanoparticles, small organic molecules, polymers, or bioactive materials), with an emphasis on the development of functional biological nanointerfaces as drug vehicles, after a simple introduction of the toxicity of CNTs. The translation of these systems into clinical practice and an outlook into future approaches are also discussed.

show abstract

“…Both theoretical and experimental works (Burgess et al, 2003;Dawson et al, 2005;Ferguson et al, 2003) have shown a high binding affinity of EGF towards the EGFR, while a kinetic study of the EGF-EGFR interaction suggested that EGF can bind with either an inactive expanded EGFR dimer or a tethered EGFR monomer before inducing the EGFR dimerization process (Björkelund, Gedda, Malmqvist, & Andersson, 2013;Lemmon, 2009 in vitro and in vivo studies on the use of EGF as targeting agent in DDS applications (Bhirde, et al, 2009;Cheng et al, 2012;Shevtsov et al, 2014;Tseng et al, 2008;Yang et al, 2009). Therefore, we aimed to investigate the structure and dynamics properties as well as the proteinprotein binding efficiency of EGFR•EGF-CS-SWCNT-Drug complex in comparison to that for the EGFR•EGF complex and individual EGFR protein by using molecular dynamics simulations (MDSs).…”

Section: Introductionmentioning

confidence: 99%

Protein–protein interactions between SWCNT/chitosan/EGF and EGF receptor: a model of drug delivery system

Rungnim

Rungrotmongkol

Kungwan

et al. 2016

Journal of Biomolecular Structure and Dynamics

View full text Add to dashboard Cite

Epidermal growth factor (EGF) was used as the targeting ligand to enhance the specificity of a cancer drug delivery system (DDS) via its specific interaction with the EGF receptor (EGFR) that is overexpressed on the surface of some cancer cells. To investigate the intermolecular interaction and binding affinity between the EGF-conjugated DDS and the EGFR, 50 ns molecular dynamics simulations were performed on the complex of tethered EGFR and EGF linked to single-wall carbon nanotube (SWCNT) through a biopolymer chitosan wrapping the tube outer surface (EGFR·EGF-CS-SWCNT-Drug complex), and compared to the EGFR·EGF complex and free EGFR. The binding pattern of the EGF-CS-SWCNT-Drug complex to the EGFR was broadly comparable to that for EGF, but the binding affinity of the EGF-CS-SWCNT-Drug complex was predicted to be somewhat better than that for EGF alone. Additionally, the chitosan chain could prevent undesired interactions of SWCNT at the binding pocket region. Therefore, EGF connected to SWCNT via a chitosan linker is a seemingly good formulation for developing a smart DDS served as part of an alternative cancer therapy.

show abstract

EGF-functionalized single-walled carbon nanotubes for targeting delivery of etoposide

Cited by 39 publications

References 46 publications

Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance

Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance

Modification Strategies for Carbon Nanotubes as a Drug Delivery System

Protein–protein interactions between SWCNT/chitosan/EGF and EGF receptor: a model of drug delivery system

Contact Info

Product

Resources

About