EGFR-Activated JAK2/STAT3 Pathway Confers Neuroprotection in Spinal Cord Ischemia–Reperfusion Injury: Evidence from High-Throughput Sequencing and Experimental Models

Lv, Shijie; Zhao, Kunchi; Li, Ran; Meng, Chunyang; Li, Guangchun; Yin, Fei

doi:10.1007/s12035-023-03548-9

Mol Neurobiol

2023

DOI: 10.1007/s12035-023-03548-9

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EGFR-Activated JAK2/STAT3 Pathway Confers Neuroprotection in Spinal Cord Ischemia–Reperfusion Injury: Evidence from High-Throughput Sequencing and Experimental Models

Shijie Lv,

Kunchi Zhao,

Ran Li

et al.

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2024

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Epidermal growth factor receptor pathway in central nervous system regenerative medicine: a narrative review

Badenes

2024

Regenerative Medicine Reports

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The epidermal growth factor receptor (signaling pathway is involved in numerous important mammal cell functions, such as growth, survival, proliferation, and differentiation. Associated with this, it is involved in tissue normal development and growth, tumorigenesis, and in tissue repair. Epidermal growth factor receptor is broadly expressed in the organism, including in the central and peripheral nervous system, where it has important neurotrophic functions. The central nervous system has a limited capacity for regeneration upon lesion, leading to severe disabilities, such as blindness, sensorimotor deficits, and paralysis. However, observations suggest that its innate neurogenic response may be amplified to promote the replenishment of damaged neuronal populations. In addition, the environment can also be modulated to promote regeneration. Therefore, the pathways involved in neural tissue repair have been investigated in terms of regenerative medicine, to discover new therapies to recover from traumatic injury or ischemia in the central nervous system or to inhibit the progression of neurodegenerative diseases. Growth factors have been widely accepted as the most important promoters of proliferation and neurogenesis under physiologic conditions and after injury. In this review, we summarize how the epidermal growth factor receptor signaling pathway is involved in neuronal damage and neurodegeneration in several settings, including in the olfactory epithelium, brain, spinal cord, and optic nerve, where this pathway can be modulated in the context of regenerative medicine to promote neuronal regeneration and, therefore, neurological function reestablishment in response to insults.

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Epidermal growth factor receptor pathway in central nervous system regenerative medicine: a narrative review

Badenes

2024

Regenerative Medicine Reports

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EGFR-Activated JAK2/STAT3 Pathway Confers Neuroprotection in Spinal Cord Ischemia–Reperfusion Injury: Evidence from High-Throughput Sequencing and Experimental Models

Cited by 1 publication

References 73 publications

Epidermal growth factor receptor pathway in central nervous system regenerative medicine: a narrative review

Epidermal growth factor receptor pathway in central nervous system regenerative medicine: a narrative review

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