EGFR exon 20 insertion mutations in Chinese advanced non-small cell lung cancer patients: Molecular heterogeneity and treatment outcome from nationwide real-world study

Gao, Yang; Li, Jun; Xu, Haiyan; Yang, Yaning; Yang, Lu; Xu, Fei; Xia, Bing; Zhu, Viola W.; Nagasaka, Misako; Yang, Yan; Ya-pin, LI; Qiu, Weini; Ying, Jianming; Ou, Sai‐Hong Ignatius; Wang, Yan

doi:10.1016/j.lungcan.2020.03.014

Cited by 78 publications

(106 citation statements)

References 30 publications

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“…Less than 10% of all EGFR ex20ins mutations occurred within the C-helix (E762 to M766). 4,14,15 It was reported that EGFR A763_Y764insFQEA, which occurred within the C-helix of EGFR, was associated with sensitivity to available TKIs. 5,6 Besides, most EGFR ex20ins mutations were resistant to available TKIs.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Besides, most EGFR ex20ins mutations were resistant to available TKIs. In 2013, Yasuda et al 4 reported the first crystal structure of a representative EGFRD770_N771insNPG, which provided valuable insights into understanding the relationship between EGFR ex20ins and EGFR activation or TKIs resistance. It revealed EGFR D770_N771insNPG located towards the C-terminal end of the C-helix, which was a key regulatory factor that activated EGFR via rotating it to form active conformation.…”

Section: Discussionmentioning

confidence: 99%

“…The median PFS was 6.4 for chemotherapy and 2.9 months for all generation TKIs. 4 Considering the aforementioned unsatisfactory results, TKIs seems not to be a good choice for patients harboring EGFR ex20ins. Until now, there are still no established molecular targeted drugs for NSCLC patients with EGFR ex20ins.…”

Section: Introductionmentioning

confidence: 99%

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Response to Afatinib in a Patient with NSCLC Harboring Novel EGFR Exon 20 Insertion Mutations

Li¹,

Wu²,

Yan³

et al. 2020

OTT

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Most epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutations are resistant to tyrosine kinase inhibitors (TKIs). While some non-small cell lung cancer (NSCLC) patients harboring special subtypes of EGFR ex20ins still achieved clinical response after TKIs treatment, identifying special subtypes of EGFR ex20ins is helpful to find out NSCLC patients who can respond to TKIs. Case Presentation: A 71-year-old non-smoker Chinese female was diagnosed with advanced lung adenocarcinoma harboring EGFR ex20ins (N771delinsKG). The patient received first-line afatinib (40 mg/day) therapy and a significant and substantial reduction in tumor size was observed subsequently. According to RESIST 1.1, a radiological partial response was achieved. The final progression-free survival was 10 months. Conclusion: This is the first published case report of EGFR N771delinsKG lung adenocarcinoma, which highlighted the heterogeneity of clinical response to TKIs for EGFR ex20ins-mutant NSCLC. Such results need to be further investigated in prospective studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Response to Afatinib in a Patient with NSCLC Harboring Novel EGFR Exon 20 Insertion Mutations

Li¹,

Wu²,

Yan³

et al. 2020

OTT

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“…Non-small cell lung cancers (NSCLC) harboring the epidermal growth factor receptor (EGFR) exon 20 insertion mutations are generally thought to be unresponsive to EGFR tyrosine kinase inhibitor (TKI) therapy [ 1 , 2 ]. Chemotherapy was superior to the currently approved EGFR TKIs as treatment for EGFR exon 20 insertion mutations [ 3 ]; however, the benefit of EGFR TKIs or chemotherapy to patients with NSCLC who harbor exon 20 insertion remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Good response with durvalumab after chemoradiotherapy for epidermal growth factor receptor exon 20 insertion adenocarcinoma: A case report

Matsuura

Morikawa

Ito

et al. 2020

Respiratory Medicine Case Reports

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Epidermal growth factor receptor (EGFR) exon 20 insertion is not associated with sensitivity to EGFR tyrosine kinase inhibitors and chemotherapy. Here, we report the case of a 41-year-old man who presented a right lower lobe nodule and mediastinal lymph node enlargement diagnosed as EGFR exon 20 insertion adenocarcinoma with high-expression programmed cell death ligand 1 (PD-L1). He showed stable disease to chemoradiation treatment at the primary tumor site. However, durvalumab treatment has good response. Non-small cell lung cancer with EGFR exon 20 insertion and high PD-L1 expression may be treated with immunotherapy exposure.

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“…Kumagai et al investigated laser ablation of polymer films of polytetrafluoroethylene, tetrafluoroethylene-hexafluoropropylene copolymer, and polyimide (PI) through multiphoton absorption using a femtosecond high-peak-power Ti:sapphire laser at 798 nm [15]. High-quality laser processing of engineering plastics of PI [16][17][18], poly(methyl methacrylate) [19][20][21], and a conducive polymer of poly (3,4-ethylenedioxythiophene) poly(styrene sulfonate) [22] has been demonstrated. However, practical applications of laser-processed engineering plastics are scarce up to date.…”

Section: Introductionmentioning

confidence: 99%

Pulsed Laser Drilling of Engineering Plastic Films to Fabricate Through-Hole Membranes for Print-and-Imprint Method

Nakamura

Seki

Nagase³

et al. 2018

Trans. Mat. Res. Soc. Japan

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Laser drilling of engineering plastic films was performed using a picosecond pulsed laser at different repetition rates for the application of through-hole membranes to laser-drilled screen printing. Four engineering plastic films of polyimide (PI), poly(ethylene terephthalate) (PET), poly(phenylene sulfide) (PPS), and poly(ether ether ketone) (PEEK) were investigated. Frustum-shaped through holes were formed with high reproducibility by laser drilling at a repetition rate of 10 kHz. Higher repetition rates induced the formation of heat affected zone around the edge of the thorough holes in the case of engineering plastic films with their low melting point. The mean diameters of through holes formed on the film surfaces of both laser entry and exit sides at the identical repetition rate increased in the order of PEEK ≈ PET < PI < PPS, which had a relationship with the optical absorption properties at the wavelength of the laser pulses. It was suggested that the PI film was appropriate to a laser-drilled through-hole membrane in terms of the shape of through holes in addition to its chemical and thermal stabilities.

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EGFR exon 20 insertion mutations in Chinese advanced non-small cell lung cancer patients: Molecular heterogeneity and treatment outcome from nationwide real-world study

Cited by 78 publications

References 30 publications

<p>Response to Afatinib in a Patient with NSCLC Harboring Novel <em>EGFR</em> Exon 20 Insertion Mutations</p>

<p>Response to Afatinib in a Patient with NSCLC Harboring Novel <em>EGFR</em> Exon 20 Insertion Mutations</p>

Good response with durvalumab after chemoradiotherapy for epidermal growth factor receptor exon 20 insertion adenocarcinoma: A case report

Pulsed Laser Drilling of Engineering Plastic Films to Fabricate Through-Hole Membranes for Print-and-Imprint Method

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