Egg-allergic patients can be safely vaccinated against influenza

Abstract

that additional factors are required. Our study also confirmed the association of FLG mutations and early-onset infantile eczema, which is in line with previous work. 6 Our ability to interrogate the role of sensitization in the relationship between FLG mutations and food allergy in a large population-based, age-matched, challenge-proved food allergy cohort is a major and novel strength of this work. There is some potential participation bias among negative control subjects (higher immediate family history of allergic diseases compared with the general population); however, such a bias would be more likely to create a false-negative than a false-positive association.In conclusion, FLG mutations do not increase the risk of food allergy over and above that of food sensitization among 1-year-old infants. These results confirm the biological plausibility that decreased skin barrier function increases the risk of food sensitization in early life, but other as yet undetermined factors are important in the conversion from food sensitization to allergy.We acknowledge the contribution of all the parents and children who participated in the study. We thank Dr Benjamin Ong for assistance with Sequenom assay design and the Royal Children's Hospital Outpatient Pathology staff for blood collection. We thank ALK-Abell o S.A., Madrid, Spain, for supplying the SPT reagents and the HealthNuts safety committee: Associate Professor Noel Cranswick

Safe vaccination of patients with egg allergy by using live attenuated influenza vaccine

“…It was not surprising that there were no immediate IgE-mediated reactions after vaccination of the children with egg allergy because the quantity of ovalbumin in LAIV is comparable with that of TIV, which has previously been shown to be safe in patients with egg allergy. 1,2 Moreover, systemic absorption of ovalbumin via intranasal vaccination is probably much lower than intramuscular administration; a recent study showed that intranasal peanut challenge of patients with documented peanut allergy and with much higher concentration of allergens than those present in LAIV was not associated with systemic reactions. 9 Furthermore, systemic absorption of corticosteroids administered intranasally is much lower than when administered orally.…”

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012

“…85 However, the greatest attention recently has been to the administration of influenza vaccines for persons with egg allergy. 86 Des Roches et al 87 combined their results with those of 26 other studies that included more than 25 patients with egg allergy receiving the influenza vaccine. The summary included 4172 patients (513 with severe allergy) receiving a total of 4729 doses without anaphylaxis, indicating a risk of anaphylaxis (95% CI) of 0% to 0.08% (95% CI among those with severe egg allergy, 0% to 0.66%).…”

Vaccine allergies

“…Such results did not significantly differ from the rate in non-egg-allergic controls [17,37,38]. The majority of these studies specifically included patients with histories of severe anaphylaxis (n=656) as a result of egg ingestion.…”