Egg yolk phosphatidylcholine alleviates DSS-induced colitis in BALB/c mice

Wen, Yunpeng; Tan, Lixin; Chen, Shuping; Wu, Na; Yao, Yao; Xu, Lilan; Xu, Mingsheng; Zhao, Yan; Tu, Yonggang

doi:10.1039/d3fo02885b

Cited by 8 publications

(1 citation statement)

References 74 publications

(98 reference statements)

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“…Dysbiosis of the gut microbiota is strongly associated with the development of UC, and gut microbiota diversity is reduced in patients with UC [46]. Furthermore, DSS-induced UC in mice results in an altered gut microbiota [47,48]. Decreases in the phylum Firmicutes and increases in Proteobacteria are the main features of UC ecological dysbiosis [46].…”

Section: Discussionmentioning

confidence: 99%

Sea Cucumber Peptides Ameliorate DSS-Induced Ulcerative Colitis: The Role of the Gut Microbiota, the Intestinal Barrier, and Macrophage Polarization

Yu,

Guo,

et al. 2023

Nutrients

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The incidence of ulcerative colitis (UC) is increasing annually. There are few treatments for UC patients, and some drugs have serious side effects. Sea cucumber peptide (SCP) has anti-inflammatory, antioxidant and other biological activities, and various sea cucumber species are in pharmaceutical development. However, relevant studies on the effects of SCP on UC progression are still lacking. In this study, a mouse model of acute colitis was induced by 3% dextran sulfate (DSS), and the effect of 500 mg/kg SCP on colitis was investigated. The results showed that SCP can alleviate DSS-induced colon damage and intestinal barrier damage. SCP significantly inhibited the expression of inflammatory factors and oxidative stress in UC mice. SCP reversed the intestinal microbiota dysregulation induced by DSS, inhibited the growth of Sutterella, Prevotella_9 and Escherichia-Shigella harmful bacteria, and increased the abundance of Lachnospiraceae_NK4A136_group. At the same time, SCP treatment significantly inhibited the LPS-induced polarization of M1 macrophages, which may be mediated by two monopeptides, IPGAPGVP and TGPIGPPGSP, via FPR2. In conclusion, SCP can protect against colitis by modulating the intestinal microbiota composition and the intestinal barrier and inhibiting the polarization of M1 macrophages.

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