Egg Yolks Inhibit Activation of NF-κB and Expression of Its Target Genes in Adipocytes after Partial Delipidation

Shen, Qiwen; Riedl, Ken M.; Cole, Rachel M.; Lehman, Christopher M.; Xu, Lu; Alder, Hansjüerg; Belury, Martha A.; Schwartz, Steven J.; Ziouzenkova, Ouliana

doi:10.1021/jf5056584

Cited by 7 publications

(11 citation statements)

References 55 publications

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“…These methods all have their own advantages and disadvantages . Some researchers have demonstrated that EYO possesses indeed some biological activities with regard to alleviating inflammation and promoting wound healing. , …”

Section: Biological Activities Of Egg Yolk Oilmentioning

confidence: 99%

Biological Activities of Egg Yolk Lipids: A Review

Xiao

Zhao

Yao

et al. 2020

J. Agric. Food Chem.

109

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As one of six dietary nutrients, lipid derived from different food matrices has been extensively studied and has an appropriate application in food, medicine, and cosmetic industry. Egg is a richly nutritive food, of which proteins and lipids possess excellent functional characteristics and biological activities. In recent years, egg yolk lipid has been successively separated and investigated, such as egg yolk oil, phospholipids, and fatty acids, which have anti-inflammatory activity, antioxidant activity, cardiovascular protection, and memory improvement, involving the regulation of cell function and physiological homeostatic balance. In this paper, the biological activities and underlying benefit of egg yolk lipids and fat-soluble components have been highlighted and summarized. Meanwhile, the quantitative data of egg yolk lipids needed to achieve any of the described biological effects and recommended concentrations relevant for dietary intake are reviewed. Finally, current challenges and crucial issues of high-efficiency utilization of egg yolk lipids are also discussed.

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Section: Biological Activities Of Egg Yolk Oilmentioning

confidence: 99%

Biological Activities of Egg Yolk Lipids: A Review

Xiao

Zhao

Yao

et al. 2020

J. Agric. Food Chem.

109

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“…Traditionally in Iran, people believed that egg yolk oil, which is extracted by direct heat possesses, has analgesic and anti-inflammatory properties (11), yet its mechanism as an anti-inflammatory agent is unclear. A study by Shen Q. et al claimed that egg yolk affects the NF-κB level in the inflammatory procedure, which is a major regulator in the transcription pathway (12). Following a partial delipidation process, egg yolk composition includes polar and nonpolar fractions.…”

Section: Introductionmentioning

confidence: 99%

“…Besides, the cholesterol and polyunsaturated fatty acids content of egg yolk suppress the pro-inflammation pathways. In fact, the activation of NF-κB (a key regulator of acute and chronic inflammation) is affected by egg yolk ingredients (12). Hence, egg yolk could be defined as an appropriate drug choice in the treatment of an anal fissure.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of egg yolk and nitroglycerin ointment as treatments for acute anal fissures: A randomized clinical trial study

Salari¹,

Salari²,

Dadgarmoghadam³

et al. 2016

Electron physician

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BackgroundAcute anal fissure as a common disease in society has several etiologies and manifestations such as severe anal pain and bleeding. Nitroglycerin ointment 0.2% is the most common topical treatment used. The most common side effect of nitroglycerin is headache, which is annoying for patients and often leads to discontinuation of the drug.ObjectiveComparison of egg yolk as a natural substance with analgesic and anti-inflammatory properties and minimal side effects with nitroglycerin ointment in the treatment of acute anal fissure.MethodsThis randomized clinical trial was carried out during a 10-day period in the Gastroenterology clinic of Ghaem Hospital, Mashhad, Iran (year 2015). 126 patients who filled the inclusion criteria were enrolled. The patients were randomly divided into two groups. Nitroglycerin ointment (0.2%) was applied by patients in the first group, twice daily for 10 days. For the second group, one egg yolk once a day was administered rectally up to 10 days. The pain and bleeding severity were recorded every two days up to 10 days after finishing the treatment course, based on visual scaleResultsThe results showed that egg yolk caused a significant reduction in pain and bleeding compared with nitroglycerin (p<0.05). At the beginning of the study, the difference in pain intensity between the two groups was not statistically significant (p-value = 0.25). However, it became significant in the following days. Changes in the frequency of rectorrhagia were also significant in both groups, showing a major decrease in the number of rectorrhagia cases (p<0.001).ConclusionEgg yolk is more efficient than nitroglycerin in the treatment of acute anal fissure. In addition, lack of any side effects results in the completion of the treatment course by the patients.Trial RegistrationThe trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: IRCT2015050718915N3.FundingThis work was supported by a grant from the Vice Chancellor of Research of Mashhad University of Medical Sciences.

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“…NanoString’s nCounter analysis (NanoString Technologies) system performed direct detection of target molecules from a single sample using color-coded molecular barcodes, giving a digital quantification of the number of target molecules as described before [35]). A custom panel containing axon guidance molecules was designed and used for simultaneous quantification of 32 axon guidance genes and 5 housekeeping genes.…”

Section: Experimental and Methodsmentioning

confidence: 99%

Induction of innervation by encapsulated adipocytes with engineered vitamin A metabolism

Shen

Yasmeen

Marbourg

et al. 2018

Translational Research

Self Cite

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Innervation is a fundamental basis for function and survival of tissues. In the peripheral tissues, degenerative diseases create a neurotoxic metabolic milieu that either causes neurodegeneration or fails to sustain regenerative growth and reinnervation of injured/diseased tissues. Encapsulation of cells producing neurotrophic factors can augment axon growth and neuron survival; however, sustained innervation in vivo requires a combination of factors promoting axon growth and guidance pathway that are released in a tissue-specific context. Using novel encapsulation techniques and genetic tools, we manipulated retinoic acid-generating enzyme aldehyde dehydrogenase 1a1 (Aldh1a1) in adipocytes that are capable of promoting growth and innervation of white adipose tissue by sympathetic neurons. Aldh1a1 adipocytes secrete molecules that regulate axon guidance and markedly stimulate neurite outgrowth in vitro and in vivo. Based on studies with natural and synthetic RAR agonists and antagonists, gene microarray and nanostring arrays, we concluded that ephrin A5/ephrin A4 is a downstream pathway regulated by Aldh1a1. Encapsulation of Aldh1a1 adipocytes into alginate poly-L-lysine microcapsules induced functional innervation of adipose tissue in obese wild-type mice. We propose that encapsulated Aldh1a1 adipocytes could provide a therapeutic solution for the reinnervation of damaged tissues.

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Egg Yolks Inhibit Activation of NF-κB and Expression of Its Target Genes in Adipocytes after Partial Delipidation

Cited by 7 publications

References 55 publications

Biological Activities of Egg Yolk Lipids: A Review

Biological Activities of Egg Yolk Lipids: A Review

Efficacy of egg yolk and nitroglycerin ointment as treatments for acute anal fissures: A randomized clinical trial study

Induction of innervation by encapsulated adipocytes with engineered vitamin A metabolism

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