This article draws on clinical, cognitive, and health psychology literature to explore a range of barriers to sexual risk behavior change. It is divided into 5 sections, each of which presents obstacles and solutions to address them. The first 4 sections are organized around antecedent factors commonly addressed in models of risk behavior. Barriers related to effective information, risk perception, attitudes and intentions, and behavioral skill acquisition are discussed. The 5th section focuses on barriers related to the psychological and social context of sexual encounters, factors relatively underexplored in traditional approaches to risk reduction. It is believed that future intervention programs will be strengthened by incorporating a more integrative and comprehensive approach to intrapersonal and interpersonal aspects of sexual behavior.