EHMTI-0233. Clinical characteristics of migraine patients with dopaminergic gene polymorphisms RS1611115

Skorobogatykh, Kirill; Azimova, Julia; Сергеев, А. В.; Климов, Е. А.; Tabeeva, G. R.; Fokina, N M; Korobeynikova, L. A.; Кокаева, З.Г.

doi:10.1186/1129-2377-15-s1-b35

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“…The dopaminergic system and glutamate also play major roles in migraine. Skorobogatykh et al did a research about dopamine beta hydroxylase (DBH) polymorphisms rs1611115 and showed that the T-allele carriers (46.9%) as compared to the CC genotype patients (53.1%) have more severe migraine (75). TT genotype of rs2049046 in brain-derived neurotrophic factor (BDNF) gene appears to influence susceptibility to migraine chronification.…”

Section: Othersmentioning

confidence: 99%

Migraine in the era of precision medicine

Zhang

Dong

Yu³

2016

Ann. Transl. Med.

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Migraine is a common neurovascular disorder in the neurologic clinics whose mechanisms have been explored for several years. The aura has been considered to be attributed to cortical spreading depression (CSD) and dysfunction of the trigeminovascular system is the key factor that has been considered in the pathogenesis of migraine pain. Moreover, three genes (CACNA1A, ATP1A2, and SCN1A) have come from studies performed in individuals with familial hemiplegic migraine (FHM), a monogenic form of migraine with aura. Therapies targeting on the neuropeptids and genes may be helpful in the precision medicine of migraineurs. 5-hydroxytryptamine (5-HT) receptor agonists and calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated efficacy in the acute specific treatment of migraine attacks. Therefore, ongoing and future efforts to find new vulnerabilities of migraine, unravel the complexity of drug therapy, and perform biomarker-driven clinical trials are necessary to improve outcomes for patients with migraine.

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Section: Othersmentioning

confidence: 99%