Ehrlichiosis in anemic, thrombocytopenic, or tick-infested dogs from a hospital population in South Brazil

Dagnone, Ana Silvia; Morais, Helio S. Autran de; Vidotto, Marilda Carlos; Jojima, Flavio Shigueru; Vidotto, Odilon

doi:10.1016/j.vetpar.2003.10.001

Cited by 88 publications

(102 citation statements)

References 10 publications

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“…A similar result was obtained by Trapp et al (7) in a canine population at a veterinary hospital in Londrina (PR), with 23% (87/381) of the dogs being seropositive for E. canis (IFAT ≥80). The results for the city of Lavras (MG) is within the range reported by other studies conducted in Brazil, which have shown that between 14% and 45% of the dogs that are attended in veterinary hospitals and clinics are seropositive (18) . The frequency of E. canis in the serum of dogs in Lavras (MG) was lower than the results observed by Silva et al (19) in Cuiaba (MT), 42.5% (108/254; IFAT ≥40), and by Souza et al (20) in Salvador (BA), 35.6% (168/472; IFAT ≥80).…”

Section: Resultssupporting

confidence: 87%

“…In this study, of the 79 (49.1%) dogs with thrombocytopenia, 20 (25.3%) had anti-E. canis antibodies, 35 (44.3%) had anti-B. vogeli antibodies, and 4 (5.1%) had antibodies for both hemoparasites, indicating that, although it is a characteristic finding, thrombocytopenia is not exclusive to canine ehrlichiosis and may be present in different diseases (18) . Thus, those dogs seronegative to E. canis and B. vogeli, but with values for hematological parameters and/or the platelet count that are low for canines, are likely infected by other hemoparasites, such as Anaplasma platys and Hepatozoon canis, which are also transmitted by the tick vector R. sanguineus (33,34) .…”

Section: Resultsmentioning

confidence: 56%

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HEMATOLOGICAL PARAMETERS AND SEROPREVALENCE OF Ehrlichia canis AND Babesia vogeli IN DOGS

et al. 2017

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The aim of this study was to determine the prevalence of anti-Ehrlichia canis and anti-Babesia vogeli IgG antibodies in dogs and correlate this prevalence with risk factors to evaluate the relation of serological status to hematological findings. Blood samples of dogs attended from September 2011 to March 2012 at the veterinary hospital of the Federal University of Lavras, Brazil, were analyzed using an indirect fluorescence antibody test (IFAT). Of the total 160 dog serum samples, 23.7% (38 dogs; CI 95 17.7% -30.7%) were seropositive for E. canis, 40.0% (64 dogs; CI 95 40.0% -59.2%) for B. vogeli, and 5.6% (9 dogs) for both hemoparasites. None of the epidemiological variables showed a significant association (P>0.05) with seropositivity to E. canis and B. vogeli. Dogs seropositive for E. canis showed lower values for hematocrit (P<0.05). However, for the erythrogram, the platelet count, the leukogram and clinical signs, no significant difference (P>0.05) was observed between dogs that were seropositive and seronegative for E. canis or for B. vogeli. Serological results suggest that infection with E. canis and B. vogeli is endemic in the canine population in question, with a prevalence of the subclinical phase (asymptomatic) in dogs that are seropositive for ehrlichiosis or babesiosis. Keywords: babesiosis; canine; ehrlichiosis; IFAT; laboratory findings. ResumoO objetivo deste estudo foi determinar a prevalência de anticorpos IgG anti-Ehrlichia canis e antiBabesia vogeli em cães e correlacionar com a prevalência e fatores de risco para avaliar a relação do estado sorológico com os achados hematológicos. Amostras de sangue de cães coletadas de setembro de 2011 a março de 2012, no Hospital Veterinário da Universidade Federal de Lavras, Brasil, foram analisadas usando o teste de reação de imunofluorescência indireta (RIFI). Do total de amostras de soro de 160 cães, 23,7% (38 cães; IC95 17,7% -30,7%) foram soropositivos para E. canis, 40,0% (64 cães; IC95 40,0% -59,2%) para B. vogeli, e 5,6% (9 cães) para os dois hemoparasitas. Nenhuma das variáveis epidemiológicas mostrou associação significativa (P> 0,05) com a soropositividade para E. canis e B. vogeli. Cães soropositivos para E. canis mostraram valores médios mais baixos para hematócrito (P<0,05). No entanto, para o eritrograma, a contagem de plaquetas, o leucograma e os sinais clínicos, nenhuma diferença significativa (P> 0,05) foi observada entre cães soropositivos e soronegativos para E. canis ou para B. vogeli. Os resultados sorológicos deste estudo sugerem que a Cienc. anim. bras., Goiânia, v.18, 1-9, e-36095, 2017 2 FONSECA, J.P., et al.infecção por E. canis e B. vogeli é endêmica na população canina em questão, com uma prevalência da fase subclínica (assintomática) em cães soropositivos para erliquiose ou babesiose.

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Section: Resultssupporting

confidence: 87%

Section: Resultsmentioning

confidence: 56%

HEMATOLOGICAL PARAMETERS AND SEROPREVALENCE OF Ehrlichia canis AND Babesia vogeli IN DOGS

et al. 2017

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“…The prevalence level observed in this study was inferior to those of similar investigations of E. canis made in several cities in the country. These included 22% in Londrina, State of Parana, (DAGNONE et al, 2003), 35.6% in Salvador, State of Bahia , and 57% in Recife, State of Pernambuco (RAMOS et al, 2010 (DINIZ et al, 2007)]. Nevertheless, the prevalence level of this study was greater than those described in the city of Rio de Janeiro, State of Rio de Janeiro, 15%, (MACIEIRA et al, 2005) and two cities in the State of Bahia: Ilheus (10.7%; 9/84) and Itabuna (4.3%; 3/69) (CARVALHO et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

“…Existing data of CME and CTA within the region of Londrina, north region of the State of Parana, is restricted to hospital cases (DAGNONE et al, 2003;TRAPP et al, 2006); no study evaluating the occurrence of these diseases in household dogs has been found. This study evaluated the occurrence of E. canis and A. platys in a population of apparently healthy household dogs within the region of Londrina, associating the presence of these agents with possible risk factors and hematological alterations.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Ehrlichia canis and Anaplasma platys in household dogs from northern Parana

Silva

Benitez

Girotto

et al. 2012

Rev. Bras. Parasitol. Vet.

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Canine monocytic ehrlichiosis caused primarily by Ehrlichia canis and canine thrombocytic anaplasmosis induced by Anaplasma platys are important emerging zoonotic tick-borne diseases of dogs. There is evidence that these pathogens can also affect humans. This study evaluated the presence of E. canis and A. platys in blood samples collected from 256 domiciled dogs in the municipality of Jataizinho, located in north region of the State of Parana, Brazil, by PCR assay. The occurrence of E. canis and A. platys was 16.4% (42/256) and 19.4% (49/256), respectively; while 5.47% (14/256) of the dogs evaluated were co-infected by these two organisms. The presence of E. canis and A. platys was not significantly associated with the variables evaluated (sex, age, outdoor access, and presence of ticks during blood collection). Infection of dogs by E. canis was associated with anemia and thrombocytopenia, while infection induced by A. platys was related only to thrombocytopenia. Canine monocytic ehrlichiosis and canine thrombocytic anaplasmosis should be included in the differential diagnoses when these hematological alterations are observed during routine laboratory evaluation of dogs.Keywords: Canine monocytic ehrlichiosis, canine thrombocytic anaplasmosis, PCR, anemia, thrombocytopenia. ResumoErliquiose monocítica canina, causada principalmente por Ehrlichia canis, e anaplasmose trombocítica canina, devida a infecção com Anaplasma platys, são importantes doenças transmitidas por carrapatos que acometem os cães, com evidências que podem também acometer o homem. O presente estudo avaliou a ocorrência desses agentes em amostras de sangue de 256 cães domiciliados na cidade de Jataizinho, na região Norte do Paraná, Brasil, utilizando a técnica da Reação em Cadeia da Polimerase (PCR). A ocorrência de E. canis e A. platys foi de 16,4% (42/256) e 19,4% (49/256), respectivamente, com 5,47% (14/256) dos animais apresentando coinfecção. Não foi observada associação significativa com as variáveis sexo, idade, acesso à rua e presença de carrapatos no momento da coleta de sangue. A infecção por E. canis teve relação com anemia e com trombocitopenia, enquanto a infecção por A. platys apresentou relação apenas com trombocitopenia. Com base nos resultados obtidos, reforçou-se a necessidade de que erliquiose e anaplasmose canina devem estar entre os diagnósticos diferenciais, quando da detecção de anemia e trombocitopenia em exames laboratoriais.

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“…Canine ehrlichiosis is a disease with high incidence among domestic dogs in Brazil (DAGNONE et al, 2003;NAKAGHI et al, 2008;FARIA et al, 2010;VIEIRA et al, 2011), with extensive mortality. It is a tick-borne disease caused by Gram-negative bacteria, of the species Ehrlichia canis, mostly transmitted by Rhipicephalus sanguineus (LEWIS et al, 1977;TROY;FORRESTER, 1990).…”

Section: Introductionmentioning

confidence: 99%

Experimental Ehrlichia canis infection changes acute-phase proteins

Munhoz

Faria

Vargas-Hérnandez

et al. 2012

Rev. Bras. Parasitol. Vet.

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Early diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease.Keywords: Ehrlichia canis, experimental infection, acute-phase proteins, dogs. ResumoO diagnóstico precoce da erliquiose canina favorece a pronta instituição do tratamento e melhora o prognóstico do animal, pois se trata de uma doença de alta mortalidade em cães. Estudos têm apontado que a determinação da concentração de proteínas de fase aguda (PFA) pode contribuir para detecção precoce de doenças e auxiliar na predição do prognóstico. O presente estudo objetivou avaliar o perfil de proteínas de fase aguda (PFA) em cães experimentalmente infectados com Ehrlichia canis, no início da infecção e após o tratamento. Além disso, se seria possível associá-las com as alterações clínico-laboratoriais durante o curso da doença. Os resultados obtidos evidenciaram que todas as PFA estudadas alteraram suas concentrações em D3 (dia 3), comparadas ao D0, atingindo concentrações máximas em D18, com exceção da ceruloplasmina e da glicoproteína ácida, cujos picos foram observados em D6 e D12, respectivamente. Concluímos que a avaliação das concentrações de PFA poderiam contribuir para o diagnóstico precoce da erliquiose canina, principalmente com relação à ceruloplasmina e glicoproteína ácida, pois seus aumentos foram anteriores ao aparecimento dos sinais clínicos e das alterações laboratoriais da doença.Palavras-chave: Ehrlichia canis, infecção experimental, proteínas de fase aguda, cães.

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Ehrlichiosis in anemic, thrombocytopenic, or tick-infested dogs from a hospital population in South Brazil

Cited by 88 publications

References 10 publications

HEMATOLOGICAL PARAMETERS AND SEROPREVALENCE OF Ehrlichia canis AND Babesia vogeli IN DOGS

HEMATOLOGICAL PARAMETERS AND SEROPREVALENCE OF Ehrlichia canis AND Babesia vogeli IN DOGS

Occurrence of Ehrlichia canis and Anaplasma platys in household dogs from northern Parana

Experimental Ehrlichia canis infection changes acute-phase proteins

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