Eicosapentaenoic Acid and Apoplexy Influence of EPA Loading on SHRSP

Abstract

Since it has been reported that eicosapentaenoic acid (EPA) has a favorable effect on the incidence of myocardial infarction,' much interest is focused on EPA including fish oils. However, it is well known that one of the main causes of death in Eskimos is cerebral bleeding, which might be related to the reduction of platelet aggregation. The purpose of this study is to investigate whether EPA plays an important role in the incidence of cerebral bleeding in the stroke-prone spontaneously hypertensive rat (SHRSP). EPIDEMIOLOGICAL BACKGROUND IN JAPANESE2Death rates by myocardial infarction and apoplexy have been studied in Tokyo and Higashi Izu (a typical fishing village). The death rates by both myocardial infarction and apoplexy were higher in Tokyo than in Higashi Izu. This was thought to be related to the higher incidence of hyperlipidemia (Type IIa and IIb) in Tokyo. Although the main cause of death in the apoplexy cases in Tokyo was cerebral infarction, it was cerebral bleeding in Higashi Izu. In connection with this, it was of interest that the incidence of hyper-EPAemia (arbitrarily designated as values over the mean + 1 SD of the levels in Tokyo) was significantly higher in Higashi Izu than in Tokyo, though the incidences of hypertension were almost similar in the both places.These results indicate that a population taking a high amount of animal fat has a high serum cholesterol level and a high incidence of arteriosclerotic vascular disease; whereas a population taking a high amount of EPA has a high serum EPA level and a high incidence of cerebral bleeding. ANIMAL EXPERIMENT Dose Response Study Subjects and MethodsForty-eight 12-week-old male SHRSP, F-65, were bred under the barrier system, where temperature and humidity were maintained at 23 * 2°C and 60 2 10%. Basic 324 YASUGI el al.: EPA & APOPLEXY 300h Y m E CI)

Dietary Lipids Impacts on Healthy Ageing

“…The survival-shortening activity of canola oil was significant when it was diluted with soybean oil at a ratio of 1:3 (dose-dependency). Fish oil prolonged the survival in the absence of NaCl-loading but EPA (eicosapentaenoic acid ethyl ester, x3) shortened the survival with 1% NaClloading [9], possibly due to a decreased production of PGE 2 that is essential for the proper functioning of the kidney.…”