2016
DOI: 10.1016/j.abb.2015.11.002
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Eicosapentaenoic acid inhibits intestinal β-carotene absorption by downregulation of lipid transporter expression via PPAR-α dependent mechanism

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Cited by 25 publications
(18 citation statements)
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“…However, the specific mechanism may differ in different cases. Raghu et al reported the inhibition of intestinal β-carotene uptake by eicosapentaenoic acid (EPA) in their recent work [19]. They studied the effect of docosahexaenoic acid (DHA) and EPA on the absorption of β-carotene in intestinal cells and animal models.…”
Section: Discussionmentioning
confidence: 99%
“…However, the specific mechanism may differ in different cases. Raghu et al reported the inhibition of intestinal β-carotene uptake by eicosapentaenoic acid (EPA) in their recent work [19]. They studied the effect of docosahexaenoic acid (DHA) and EPA on the absorption of β-carotene in intestinal cells and animal models.…”
Section: Discussionmentioning
confidence: 99%
“…In agreement with these results dietary fat reported to impact on micellarization but not on intestinal uptake (Huo et al 2007). Alternatively, preconditioning of intestinal cells with fatty acids reported to increase or decrease the uptake and transcellular transport of carotenoids (Failla et al 2014;Mashurabad et al 2016). Therefore, the effects of fatty acids on intestinal carotenoid absorption are likely to be mediated by post-absorptive mechanisms via modulating the lipid transporter expression rather than micellar fat composition per se.…”
Section: Discussionmentioning
confidence: 99%
“…The intestinal absorption of carotenoids from mixed micelles is mediated by various proteins including SR-B1 and NPC1L1 (Mashurabad et al 2016;Reboul 2013). The carotene structure and micellar lipid composition might influence the intestinal cell uptake of carotenoids from mixed micelles.…”
Section: Discussionmentioning
confidence: 99%
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“…These included ABCA1, ABCG5, BCO1, 515 CD36, ELOVL2 (ELOVL fatty acid elongase 2), and ISX. Interestingly, one SNP in ELOVL2 516 (rs9468304) was very strongly associated with all three phenotypes, possibly due to the 517 inhibitory effect of eicosapentaenoic acid, which is further elongated to docosapentaenoic 518 acid and docosahexaenoic acid by ELOVL2, on carotenoid absorption, as has been shown 519 with β-carotene (Mashurabad, et al, 2016). 520 521…”
Section: A C C E P T E D Accepted Manuscriptmentioning
confidence: 97%