eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation

Min, Kyung‐Won; Davila, Sylvia; Zealy, Richard W.; Lloyd, Lawson T.; Lee, In Young; Lee, Rumi; Roh, Kyung Hye; Jung, Ahjin; Jemielity, Jacek; Choi, Eui Ju; Chang, Jeong Ho; Yoon, Je‐Hyun

doi:10.1016/j.bbagrm.2017.05.002

Cited by 36 publications

(34 citation statements)

References 45 publications

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“…In addition to being spliced and polyadenylated, lncRNA translation is controlled by regulatory proteins. An example of this is seen in the activation of eukaryotic initiation factor 4E (eIF4E) via phosphorylation by mammalian Ste20-like kinase (MST1) (19). Once active, eIF4E binds to the 5= cap of a subset of mRNAs (eIF2-␣, eukaryotic translation elongation factor 2 [eEF2], and CCT2) to inhibit their translation (19).…”

Section: Posttranscriptional Regulation and Functions Of Micropeptidesmentioning

confidence: 99%

“…An example of this is seen in the activation of eukaryotic initiation factor 4E (eIF4E) via phosphorylation by mammalian Ste20-like kinase (MST1) (19). Once active, eIF4E binds to the 5= cap of a subset of mRNAs (eIF2-␣, eukaryotic translation elongation factor 2 [eEF2], and CCT2) to inhibit their translation (19). This allows for the translation of the lncRNA linc00689, which codes for the stress-and tumor necrosis factor alpha (TNF-␣)activated ORF micropeptide (STORM), which competes with the SRP19, a ribonucleoprotein, for 7SL RNA, which may prevent proper localization of translation products to the endoplasmic reticulum (19).…”

Section: Posttranscriptional Regulation and Functions Of Micropeptidesmentioning

confidence: 99%

“…Once active, eIF4E binds to the 5= cap of a subset of mRNAs (eIF2-␣, eukaryotic translation elongation factor 2 [eEF2], and CCT2) to inhibit their translation (19). This allows for the translation of the lncRNA linc00689, which codes for the stress-and tumor necrosis factor alpha (TNF-␣)activated ORF micropeptide (STORM), which competes with the SRP19, a ribonucleoprotein, for 7SL RNA, which may prevent proper localization of translation products to the endoplasmic reticulum (19). Thus, the expression of some micropeptides can be induced under specific conditions.…”

Section: Posttranscriptional Regulation and Functions Of Micropeptidesmentioning

confidence: 99%

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When Long Noncoding Becomes Protein Coding

Hartford

Lal

2020

Molecular and Cellular Biology

128

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Recent advancements in genetic and proteomic technologies have revealed that more of the genome encodes proteins than originally thought possible. Specifically, some putative long noncoding RNAs (lncRNAs) have been misannotated as noncoding. Numerous lncRNAs have been found to contain short open reading frames (sORFs) which have been overlooked because of their small size. Many of these sORFs encode small proteins or micropeptides with fundamental biological importance. These micropeptides can aid in diverse processes, including cell division, transcription regulation, and cell signaling. Here we discuss strategies for establishing the coding potential of putative lncRNAs and describe various functions of known micropeptides.

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Section: Posttranscriptional Regulation and Functions Of Micropeptidesmentioning

confidence: 99%

Section: Posttranscriptional Regulation and Functions Of Micropeptidesmentioning

confidence: 99%

Section: Posttranscriptional Regulation and Functions Of Micropeptidesmentioning

confidence: 99%

See 1 more Smart Citation

When Long Noncoding Becomes Protein Coding

Hartford

Lal

2020

Molecular and Cellular Biology

128

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“…Micropeptides also participate in signaling pathways. For example, stress-and tumor necrosis factor (TNF)α-activated ORF micropeptide (STORM) derived from linc00689 is actuated by TNF-α-induced and mammalian ste20-like kinase mediated phosphorylation of translation initiation factor eIF4E [67]. In addition, the micropeptide Toddler accelerates gastrulation by activating APJ/Apelin receptor signaling [68].…”

Section: Signalingmentioning

confidence: 99%

Emerging role of long noncoding RNA-encoded micropeptides in cancer

Ye¹,

Zhang²,

Wang³

et al. 2020

Cancer Cell Int

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Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. The widespread applications of ribosome profiling and ribosome nascent chain complex sequencing revealed that some short open reading frames of lncRNAs have micropeptide-coding potential. The resulting micropeptides have been shown to participate in N6-methyladenosine modification, tumor angiogenesis, cancer metabolism, and signal transduction. This review summarizes current information regarding the reported roles of lncRNA-encoded micropeptides in cancer, and explores the potential clinical value of these micropeptides in the development of anti-cancer drugs and prognostic tumor biomarkers.

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“…The translation of some smORFs was triggered by mammalian Ste20-like kinase (MST1)-mediated eIF4E phosphorylation. Once phosphorylated, eIF4E could barely interact with the 5' cap of mRNA and then make polyribosomes associated with lncRNAs 94 . Other smORFs used non-ATG start codons 95 .…”

Section: The Underlying Coding Mechanisms Of Ncrnasmentioning

confidence: 99%

Encoding activities of non-coding RNAs

Pang¹,

Mao²,

Liu³

2018

Theranostics

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The universal expression of various non-coding RNAs (ncRNAs) is now considered the main feature of organisms' genomes. Many regions in the genome are transcribed but not annotated to encode proteins, yet contain small open reading frames (smORFs). A widely accepted opinion is that a vast majority of ncRNAs are not further translated. However, increasing evidence underlines a series of intriguing translational events from the ncRNAs, which were previously considered to lack coding potential. Recent studies also suggest that products derived from such novel translational events display important regulatory functions in many fundamental biological and pathological processes. Here we give a critical review on the potential coding capacity of ncRNAs, in particular, about what is known and unknown in this emerging area. We also discuss the possible underlying coding mechanisms of these extraordinary ncRNAs and possible roles of peptides or proteins derived from the ncRNAs in disease development and theranostics. Our review offers an extensive resource for studying the biology of ncRNAs and sheds light into the use of ncRNAs and their corresponding peptides or proteins for disease diagnosis and therapy.

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eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation

Cited by 36 publications

References 45 publications

When Long Noncoding Becomes Protein Coding

When Long Noncoding Becomes Protein Coding

Emerging role of long noncoding RNA-encoded micropeptides in cancer

Encoding activities of non-coding RNAs

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