“…In the second approach, a model is realized as a discretized version of equations in continuous time and space (21,22); this approach opens models up to analysis using mean-field theory, stochastic analysis, statistical physics, and kinetic theory (23)(24)(25)(26). A large and sophisticated toolset of statistical methods exists to estimate parameters, interaction kernels, or network structures from data, such as maximum likelihood estimators (27)(28)(29)(30)(31), Markov chain Monte Carlo methods based on a Bayesian paradigm (32)(33)(34)(35), martingale estimators (36), estimation of active terms in ODE and PDE systems (see ref. 37 for a review), entropy maximization (38), and regression-based learning methods (39,40).…”