Eight Days of Water-Only Fasting Promotes Favorable Changes in the Functioning of the Urogenital System of Middle-Aged Healthy Men

Letkiewicz, Sławomir; Pilis, Karol; Ślęzak, Andrzej; Pilis, Anna; Pilis, Wiesław; Żychowska, Małgorzata; Langfort, Józef

doi:10.3390/nu13010113

Cited by 6 publications

(3 citation statements)

References 97 publications

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“…Cortisol induces TDO activity, enhancing breakdown of TRP to KYN [31]. Moreover, cortisol concentration significantly increases after 8 or 10 days of water-only fasting in males and females [32,33].…”

Section: Discussionmentioning

confidence: 93%

Exploring the effect of prolonged fasting on kynurenine pathway metabolites and stress markers in healthy male individuals

Louvrou,

Solianik,

Brazaitis

et al. 2024

Eur J Clin Nutr

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Background/objectives Prolonged fasting triggers a stress response within the human body. Our objective was to investigate the impact of prolonged fasting, in conjunction with stress, on kynurenine pathway metabolites. Subjects/methods Healthy males were divided into fasting group (zero-calorie-restriction) for 6 days (FAST, n = 14), and control group (CON, n = 10). Blood and saliva samples were collected at baseline, Day 2, Day 4, Day 6 during fasting period, and 1 week after resuming regular diet. Plasma levels of kynurenine pathway metabolites were measured using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Plasma and salivary samples were analyzed for stress markers. Results A pronounced activation of the kynurenine pathway in individuals on FAST trial was revealed. Concentrations of picolinic acid (PIC), kynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK) were significantly increased, with peak levels observed on Day 6 (P < 0.0001). Conversely, concentrations of tryptophan (TRP) and quinolinic acid (QUIN) decreased (P < 0.0001), while kynurenine (KYN) and nicotinamide (NAM) levels remained stable. Cortisol and noradrenaline concentrations remained unchanged. However, adrenaline levels significantly increased on Day 4 within FAST compared to CON (P = 0.005). Notably, all deviations in kynurenine pathway metabolite levels returned to baseline values upon resuming regular diet following the 6-day fasting regimen, even when weight and BMI parameters were not restored. Conclusions Extended fasting over 6 days induces the kynurenine pathway and has minimal effects on stress markers. Restoration of metabolite concentrations upon regular feeding implies rapid adaptation of the kynurenine pathway synthetic enzymes to maintain homeostasis when faced with perturbations.

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Section: Discussionmentioning

confidence: 93%

Exploring the effect of prolonged fasting on kynurenine pathway metabolites and stress markers in healthy male individuals

Louvrou,

Solianik,

Brazaitis

et al. 2024

Eur J Clin Nutr

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“…The most easily observed effect of fasting is weight loss, which is also associated with a decrease in fat content and often with lower fat-free mass (FFM). These changes were observed after complete fasting [25], after CR and IF [17,40], and after ADF. After 12 weeks of using ADF combined with endurance exercises and ADF alone, body weight of obese people decreased by 6.0 ± 4.0 kg and 3.0 ± 1.0 kg, respectively, and fat mass and waist circumference were also significantly reduced, with FFM unchanged only in the first group [5].…”

Section: Introductionmentioning

confidence: 79%

Effect of 8 days of water-only fasting and vigorous exercise on anthropometric parameters, lipid profile and HOMA-IR in middle-aged men

Pilis,

Stec

et al. 2023

Biomedical Human Kinetics

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Study aim: The aim of the present study was to determine the effect of 8 days of water-only fasting and physical exercise on somatic variables, lipid profile, insulin resistance and cardiovascular function in middle-aged men. Material and methods: Body weight, body composition, lipid profile, serum concentrations of insulin, glucose, β-hydroxybutyrate (β-HB), heart rate (HR), blood pressure and the homeostasis model assessment of insulin resistance (HOMA-IR) were determined in 16 apparently healthy men at rest and after aerobic exercise. This test procedure was also repeated after 8 days of water-only fasting. Results: Fasting intervention resulted in a reduction in body weight and fat mass (p < 0.001). The simultaneous effect of fasting and exercise resulted in significant changes in lipid profile, carbohydrate metabolism and cardiovascular function. Post hoc analyses showed that the reductions in insulin and glucose concentrations as well as the HOMA-IR index were caused by the fasting, and changes in the lipid profile and cardiovascular function were caused by the exercise test. Conclusion: The combined use of fasting and physical effort resulted in an optimal effect on health indicators of the surveyed men.

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“…The prostate is a sex accessory organ, and pathological changes in the prostate and the progression of prostatitis are closely related to sex hormones and their receptors ( Letkiewicz et al, 2020 ). In addition, prostate gland lesions and the occurrence and development of prostatitis are closely related to sex hormones and their receptors, and a sex hormone imbalance is the main reason for class IIIB prostatitis ( Lan et al, 2017 ).…”

Section: Main Factors Causing Prostatitismentioning

confidence: 99%

Therapeutic Applications of Functional Nanomaterials for Prostatitis

Liu

Chen

et al. 2021

Front. Pharmacol.

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Prostatitis is a common disease in adult males, with characteristics of a poor treatment response and easy recurrence, which seriously affects the patient’s quality of life. The prostate is located deep in the pelvic cavity, and thus a traditional infusion or other treatment methods are unable to easily act directly on the prostate, leading to poor therapeutic effects. Therefore, the development of new diagnostic and treatment strategies has become a research hotspot in the field of prostatitis treatment. In recent years, nanomaterials have been widely used in the diagnosis and treatment of various infectious diseases. Nanotechnology is a promising tool for 1) the accurate diagnosis of diseases; 2) improving the targeting of drug delivery systems; 3) intelligent, controlled drug release; and 4) multimode collaborative treatment, which is expected to be applied in the diagnosis and treatment of prostatitis. Nanotechnology is attracting attention in the diagnosis, prevention and treatment of prostatitis. However, as a new research area, systematic reviews on the application of nanomaterials in the diagnosis and treatment of prostatitis are still lacking. In this mini-review, we will highlight the treatment approaches for and challenges associated with prostatitis and describe the advantages of functional nanoparticles in improving treatment effectiveness and overcoming side effects.

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Eight Days of Water-Only Fasting Promotes Favorable Changes in the Functioning of the Urogenital System of Middle-Aged Healthy Men

Cited by 6 publications

References 97 publications

Exploring the effect of prolonged fasting on kynurenine pathway metabolites and stress markers in healthy male individuals

Exploring the effect of prolonged fasting on kynurenine pathway metabolites and stress markers in healthy male individuals

Effect of 8 days of water-only fasting and vigorous exercise on anthropometric parameters, lipid profile and HOMA-IR in middle-aged men

Therapeutic Applications of Functional Nanomaterials for Prostatitis

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