Eight SNPs of the Myf5 gene and diplotypes associated with growth and reproductive traits in Jinghai yellow chicken

Ying, Tang; Zhang, Tao; Zhang, Genxi; Wang, Jinyu; Fan, Qingcan; Chen, Xuesen; Yue, Wei; Han, Kai; Wang, Yongjuan

doi:10.1007/s11033-014-3569-8

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…SNPs on the same chromosome do not exist alone, and adjacent-allele SNPs may work simultaneously, indicating LD [25]. The use of haplotypes in association studies to identify common variants may be more effective than single allele studies [26,27].…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Single Nucleotide Polymorphisms in the 5′ Regulatory Region of the IL-6 Gene with Eimeria tenella Resistance in Jinghai Yellow Chickens

Zou

Xin

et al. 2019

Genes

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Interleukin 6 (IL-6) is an immunoregulatory cytokine involved in various inflammatory and immune responses. To investigate the effects of single nucleotide polymorphisms (SNPs) and haplotypes of IL-6 on resistance to Eimeria tenella (E. tenella), SNPs in the 5′ regulatory region of IL-6 were detected with direct sequencing, and the effects of SNPs and haplotypes on resistance to E. tenella were analyzed by the least square model in Jinghai yellow chickens. Nineteen SNPs were identified in the 5′ regulation region of IL-6, among which three SNPs were newly discovered. The SNP association analysis results showed that nine of the SNPs were significantly associated with E. tenella resistance indexes; the A-483G locus was significantly associated with the GSH-Px, IL-2, and IL-17 indexes (p < 0.05); the C-447G locus was significantly associated with the SOD, GSH-Px, IL-17, and IL-2 indexes (p < 0.05); and the G-357A locus had significant effects on the CAT and IL-16 indexes (p < 0.05). Haplotype analysis showed that H2H3 and H2H5 were favorable haplotype combinations with good coccidium resistance. Furthermore, we used qRT-PCR and observed that the expression of IL-6 in the infection group was higher than that in the control group in the liver, proventriculus, small intestine, thymus, kidney, and bursa of Fabricius and extremely significantly different than that in the cecum especially (p < 0.01). In summary, SNPs and haplotypes in the 5′ regulatory region of IL-6 have important effects on E. tenella resistance, and the results will provide a reference for molecular marker selection of E. tenella resistance in Jinghai yellow chickens.

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Section: Discussionmentioning

confidence: 99%

Association Analysis of Single Nucleotide Polymorphisms in the 5′ Regulatory Region of the IL-6 Gene with Eimeria tenella Resistance in Jinghai Yellow Chickens

Zou

Xin

et al. 2019

Genes

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“…Upon fitting a growth curve for Jinghai Yellow chicken, the inflexion point for growth was shown to occur at 11.42 weeks of age [11]. This breed has been used for studies on chicken growth and carcass traits [12, 13]. A genome-wide association study on this breed showed that a total of 18 single-nucleotide polymorphisms (SNPs) were significantly (P < 1.80E −6 ) associated with growth traits [14].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic profile of leg muscle during early growth in chicken

Xue

Zhang

et al. 2017

PLoS ONE

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The early growth pattern, especially the age of peak growth, of broilers affects the time to market and slaughter weight, which in turn affect the profitability of the poultry industry. However, the underlying mechanisms regulating chicken growth and development have rarely been studied. This study aimed to identify candidate genes involved in chicken growth and investigated the potential regulatory mechanisms of early growth in chicken. RNA sequencing was applied to compare the transcriptomes of chicken muscle tissues at three developmental stages during early growth. In total, 978 differentially expressed genes (DEGs) (fold change ≥ 2; false discovery rate < 0.05) were detected by pairwise comparison. Functional analysis showed that the DEGs are mainly involved in the processes of cell growth, muscle development, and cellular activities (such as junction, migration, assembly, differentiation, and proliferation). Many of the DEGs are well known to be related to chicken growth, such as MYOD1, GH, IGF2BP2, IGFBP3, SMYD1, CEBPB, FGF2, and IGFBP5. KEGG pathway analysis identified that the DEGs were significantly enriched in five pathways (P < 0.1) related to growth and development: extracellular matrix–receptor interaction, focal adhesion, tight junction, insulin signaling pathway, and regulation of the actin cytoskeleton. A total of 42 DEGs assigned to these pathways are potential candidate genes inducing the difference in growth among the three developmental stages, such as MYH10, FGF2, FGF16, FN1, CFL2, MAPK9, IRS1, PHKA1, PHKB, and PHKG1. Thus, our study identified a series of genes and several pathways that may participate in the regulation of early growth in chicken. These results should serve as an important resource revealing the molecular basis of chicken growth and development.

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“…It is considered as a national cultivated meat breed characterized by its adaptability to poor quality feeds and environment (Zhao et al, 2012). According to previous studies, the Jinghai yellow chicken could be considered as a promising meat breed in terms of growth as many detected single nucleotide polymorphisms (SNPs) were associated with their growth and reproductive traits (Tang et al, 2014;Abdalhag et al, 2015;Zhang et al, 2015a;Wang et al, 2016). Insulin-like growth factors, IGF-I and IGF-II, are mitogenic polypeptides with a structure similar to insulin, and play an important role in the overall body and muscle growth in many species (Rotwein, 1991).…”

Section: Introductionmentioning

confidence: 99%

Association analysis of IGF-I gene expression with growth and reproductive traits in Jinghai yellow chickens

Abdalhag¹,

Li²,

Duan³

et al. 2016

Genet. Mol. Res.

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The insulin-like growth factor, IGF-I, plays an important role in the development of growth and reproductive traits. Single-strand conformation polymorphism analysis was used to detect and analyze polymorphisms and expression profiles of the IGF-I gene and its association with growth and reproductive traits of Jinghai yellow chickens. A point mutation g.295T>C was detected in the IGF-I gene with three genotypes CC, CT, and TT. The CT and TT genotypes were found to be significantly (P < 0.05) superior to the CC genotype in 8-, 10-, 12-, 14-, and 16-week-age weight of chickens (for growth traits) and in body weight at first egg-laying (for reproductive traits). Comparison of the expression level between males and females showed similarity in their expression curves, with females showing relatively higher IGF-I expression than males in all studied tissues. A similar IGF-I expression pattern was observed in the breast and leg muscles of both males and females, with the leg muscle showing relative higher IGF-I expression than the breast muscle. Our results indicate that, g.295T>C mutation in the IGF-I gene affects certain growth and reproductive traits, and it could be used to provide a theoretical basis as well as marker-assisted selection to upgrade the development of Jinghai yellow chickens in future.

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Eight SNPs of the Myf5 gene and diplotypes associated with growth and reproductive traits in Jinghai yellow chicken

Cited by 8 publications

References 25 publications

Association Analysis of Single Nucleotide Polymorphisms in the 5′ Regulatory Region of the IL-6 Gene with Eimeria tenella Resistance in Jinghai Yellow Chickens

Association Analysis of Single Nucleotide Polymorphisms in the 5′ Regulatory Region of the IL-6 Gene with Eimeria tenella Resistance in Jinghai Yellow Chickens

Transcriptomic profile of leg muscle during early growth in chicken

Association analysis of IGF-I gene expression with growth and reproductive traits in Jinghai yellow chickens

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