Eight Weeks of Exercise Training Improves Fitness Measures in Methamphetamine-Dependent Individuals in Residential Treatment

Dolezal, Brett A.; Chudzynski, Joy; Storer, Thomas W.; Abrazado, Marlon; Peñate, Jose; Mooney, Larissa; Dickerson, Daniel; Rawson, Richard A.; Cooper, Christopher B.

doi:10.1097/adm.0b013e318282475e

Cited by 82 publications

(100 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Out of 125 subjects randomized to date, 40 have completed the exercise intervention and 41 have completed the education intervention. Preliminary findings related to physical outcomes demonstrate a significant benefit of exercise compared to health education in improving maximum oxygen uptake, muscle strength and endurance, body mass index (BMI), percent body fat [66], and heart rate variability [67]. Additional results related to primary and secondary outcomes will be reported in future publications.…”

Section: Current Status Of the Studymentioning

confidence: 99%

Exercise for methamphetamine dependence: Rationale, design, and methodology

Mooney

Cooper

London³

et al. 2014

Contemporary Clinical Trials

Self Cite

View full text Add to dashboard Cite

Background Effective pharmacotherapies to treat methamphetamine (MA) dependence have not been identified, and behavioral therapies are marginally effective. Based on behavioral studies demonstrating the potential efficacy of aerobic exercise for improving depressive symptoms, anxiety, cognitive deficits, and substance use outcomes, the study described here is examining exercise as a potential treatment for MA-dependent individuals. Methods This study is randomizing 150 participants with MA dependence at a residential treatment facility for addictive disorders to receive either a thrice-weekly structured aerobic and resistance exercise intervention or a health education condition. Recruitment commenced in March, 2010. Enrollment and follow-up phases are ongoing, and recruitment is exceeding targeted enrollment rates. Conclusions Seeking evidence for a possibly effective adjunct to traditional behavioral approaches for treatment of MA dependence, this study is assessing the ability of an 8-week aerobic and resistance exercise protocol to reduce relapse to MA use during a 12-week follow-up period after discharge from residential-based treatment. The study also is evaluating improvements in health and functional outcomes during and after the protocol. This paper describes the design and methods of the study.

show abstract

Section: Current Status Of the Studymentioning

confidence: 99%

Exercise for methamphetamine dependence: Rationale, design, and methodology

Mooney

Cooper

London³

et al. 2014

Contemporary Clinical Trials

Self Cite

View full text Add to dashboard Cite

show abstract

“…For a detailed description of study procedures, see Mooney et al, 2013. Inclusion criteria were MA dependence per DSM-IV, age 18-45 years for men and age 18-55 years for women (per American College of Sports Medicine [ACSM, 2000] guidelines for supervision of exercise with non-physicians), vital sign stability, and ability to comply with study procedures.…”

Section: Participantsmentioning

confidence: 99%

“…Research from the present study authors has shown that an 8-week structured aerobic exercise intervention administered during residential treatment is effective in improving psychosocial and health outcomes in MA-dependent individuals, relative to health education. Dolezal et al (2013Dolezal et al ( , 2014) observed significant improvements in MA users assigned to the exercise intervention across a battery of fitness measures, including aerobic performance, muscle strength and endurance, body composition (reduced weight, percent body fat and fat weight), and heart rate variability. In addition, participation in the exercise program led to improved mood symptoms, including reduced anxiety and depression symptoms over the 8-week study period (Rawson et al, 2015) and improvement in mood functioning among clients with greater medical and psychiatric impairment (Haglund et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Impact of an exercise intervention on methamphetamine use outcomes post residential treatment care

Rawson

Chudzynski

Gonzales-Castaneda

et al. 2015

Drug and Alcohol Dependence

Self Cite

View full text Add to dashboard Cite

Background-We examined the efficacy of an 8-week exercise intervention on posttreatment methamphetamine (MA) use among MA-dependent individuals following residential treatment.Methods-135 individuals newly enrolled in treatment were randomly assigned to a structured 8-week exercise intervention or health education control group. Approximately 1 week after completion of the intervention, participants were discharged to the community. Interview data and urine samples were collected at 1-, 3-, and 6-months post-residential care. Of the sample, 54.8% were classified as higher severity users (using MA more than 18 days in the month before admission) and 45.2% as lower severity users (using MA for up to 18 days in the month before admission). Group differences in MA use outcomes were examined over the 3 timepoints using mixed-multivariate modeling.Results-While fewer exercise participants returned to MA use compared to education participants at 1-, 3-and 6-months post-discharge, differences were not statistically significant. A significant interaction for self-reported MA use and MA urine drug test results by condition and MA severity was found: lower severity users in the exercise group reported using MA significantly fewer days at the three post-discharge timepoints than lower severity users in the ContributorsAuthors RAR, LM, and CBC were involved with the design the study. Authors RG, JC, BAS managed literature searches and summaries of previous related work. Authors JP, DD, and BD undertook behavioral and clinical data collection. AA and RG undertook the statistical analysis. All authors contributed to the writing of the manuscript, including the review and final approval of it for publication. Conflicts of interest: none.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript education group. Lower severity users in the exercise group also had a lower percentage of positive urine results at the three timepoints than lower severity users in the education group. These relationships were not present in the comparison of the higher severity conditions. Conclusion-Resultssupport the value of exercise as a treatment component for individuals using MA 18 or fewer days/month.

show abstract

“…In three methodologically robust RCTs, exercise therapy was found to yield significant improvement in methamphetamine withdrawal symptoms such as craving as well as accompanying symptoms such as anxiety and depression (16)(17)(18). Professionally led, structured exercise programs conduced several times a week, with varying intensity, were studied, as well as an exercise program conducted by the patients themselves.…”

Section: Further Treatmentsmentioning

confidence: 99%