Eimeria maxima gametocyte antigens: potential use in a subunit maternal vaccine against coccidiosis in chickens

Wallach, Michael; Smith, Nicholas C.; Petracca, Maria; Miller, Catherine M.; Eckert, Johannes; Braun, Richard

doi:10.1016/0264-410x(95)98255-9

Cited by 104 publications

(69 citation statements)

References 12 publications

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“…We have shown in this study that the three major strains of influenza virus we have tested (H1N1, H3N2, and H5N1) are highly immunogenic in hens (when tested alone or in combination) and can induce a very-high-titer, long-lasting humoral immune response of at least 2 months without the need for additional boosts. In other studies, it was shown that hens maintain a high antibody titer against a variety of antigens used for immunization for atleast 3 to 4 months (16). Furthermore, in this study we tested commercially available viral strains used in the production of seasonal influenza vaccines for the U.S. market.…”

Section: Discussionmentioning

confidence: 99%

Cross-Protection of Chicken Immunoglobulin Y Antibodies against H5N1 and H1N1 Viruses Passively Administered in Mice

Wallach¹,

Webby²,

Islam³

et al. 2011

Clin. Vaccine Immunol.

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Influenza viruses remain a major threat to global health due to their ability to undergo change through antigenic drift and antigenic shift. We postulated that avian IgY antibodies represent a low-cost, effective, and well-tolerated approach that can easily be scaled up to produce enormous quantities of protective antibodies. These IgY antibodies can be administered passively in humans (orally and intranasally) and can be used quickly and safely to help in the fight against an influenza pandemic. In this study, we raised IgY antibodies against H1N1, H3N2, and H5N1 influenza viruses. We demonstrated that, using whole inactivated viruses alone and in combination to immunize hens, we were able to induce a high level of anti-influenza virus IgY in the sera and eggs, which lasted for at least 2 months after two immunizations. Furthermore, we found that by use of in vitro assays to test for the ability of IgY to inhibit hemagglutination (HI test) and virus infectivity (serum neutralization test), IgYs inhibited the homologous as well as in some cases heterologous clades and strains of viruses. Using an in vivo mouse model system, we found that, when administered intranasally 1 h prior to infection, IgY to H5N1 protected 100% of the mice against lethal challenge with H5N1. Of particular interest was the finding that IgY to H5N1 cross-protected against A/Puerto Rico/8/34 (H1N1) both in vitro and in vivo. Based on our results, we conclude that anti-influenza virus IgY can be used to help prevent influenza virus infection.

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Section: Discussionmentioning

confidence: 99%

Cross-Protection of Chicken Immunoglobulin Y Antibodies against H5N1 and H1N1 Viruses Passively Administered in Mice

Wallach¹,

Webby²,

Islam³

et al. 2011

Clin. Vaccine Immunol.

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“…The previous study made by the combination method of drugarrested development and transfer of infective mucosal preparations concluded that the 2nd-generation schizogenic stages were most important to stimulate protective immunity against E. maxima [18]. In contrast, studies reported that sporozoites could induce substantial protective immune responses although related with some intracellular metabolism [8][9][10], and gametocyte preparations were also shown to induce immunity to challenge [21,22]. As described above, the previously published data suggest that various developmental stages of parasite can induce substantial immunity.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between the Anticoccidial Effects of Clindamycin and the Development of Immunity in the Eimeria pragensis/Mouse Model of Large Intestinal Coccidiosis

Yunus

Horii

Makimura

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. The therapeutic effect of clindamycin on Eimeria pragensis (E. pragensis) infection in C57BL/6 mice was demonstrated by suppression of oocyst production and the appearance of degenerated endogenous stages of parasite in the intestine. Short-term clindamycin treatment, from 1 to 4 days or 4 to 8 days post infection (pi) at a dose of 800 mg/kg/day was effective to reduce clinical symptoms, oocyst production and schizogonic development. Interestingly, the short-term treatment schedules allowed the development of a measurable degree of protective immunity to challenge infection in the treated mice. In contrast, clindamycin treatment for the full 12 days period, which almost completely inhibited clinical symptoms and oocyst output, prevented the full development of protective immunity in the treated mice. All these data indicate that clindamycin is efficacious as an anti-eimerian agent and that both early and late endogenous developmental stages of E. pragensis exert a deep influence on the development of effective immunity to challenge infection. KEY WORDS: clindamycin, C57BL/6 mouse, degenerate endogenous stages, E. pragensis, oocyst production.

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“…In a separate study, Wallach and colleagues (Pugatsch et al, 1989) began to demonstrate that antigens recovered from the sexual stages of E. maxima and injected with an adjuvant could protect the young offspring of vaccinated hens against coccidial infections; that is, through the passively transferred maternal IgGmediated immunization (Wallach et al, 1995). Protection afforded by this strategy was wider than with live vaccines (chickens vaccinated with antigens from E. maxima alone were protected against subsequent challenge with other species) and in the 1990s the first sub-unit vaccine against coccidiosis, Coxabic † , was introduced.…”

Section: Setting the Scenementioning

confidence: 99%

The long view: a selective review of 40 years of coccidiosis research

Shirley¹,

Lillehoj

2012

Avian Pathology

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This selective review of 40 years of coccidiosis research is one of a number on important diseases of poultry to celebrate the 40th anniversary of the birth of Avian Pathology, the journal of the World Veterinary Poultry Association, and is written for the non-specialist. The intention is to provide a flavour of the field problems and intellectual challenges, with emphasis in the areas of immunology and vaccinology that drove research in the 1970s, and to reflect on research progress since.

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Eimeria maxima gametocyte antigens: potential use in a subunit maternal vaccine against coccidiosis in chickens

Cited by 104 publications

References 12 publications

Cross-Protection of Chicken Immunoglobulin Y Antibodies against H5N1 and H1N1 Viruses Passively Administered in Mice

Cross-Protection of Chicken Immunoglobulin Y Antibodies against H5N1 and H1N1 Viruses Passively Administered in Mice

The Relationship Between the Anticoccidial Effects of Clindamycin and the Development of Immunity in the Eimeria pragensis/Mouse Model of Large Intestinal Coccidiosis

The long view: a selective review of 40 years of coccidiosis research

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