2012
DOI: 10.1016/j.vaccine.2012.02.002
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Eimeria species parasites as novel vaccine delivery vectors: Anti-Campylobacter jejuni protective immunity induced by Eimeria tenella-delivered CjaA

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Cited by 73 publications
(66 citation statements)
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“…The idea of using Eimeria parasites as multivalent vaccine vectors was suggested several years ago, and to date some partial success has been reported. Clark et al [10] expressed Campylobacter jejuni antigen CjaA in E. tenella and whilst birds immunised with the transgenic parasites were protected (~90 % reduction in C. jejuni in the caeca 2 weeks after challenge, compared to controls) evidence of immunological recognition of the antigen by the chicken was inconclusive. Moreover, Liu et al [11] generated parasites expressing the M2 protein of the avian influenza virus, but found no evidence of antibody or cellular responses.…”
Section: Discussionmentioning
confidence: 99%
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“…The idea of using Eimeria parasites as multivalent vaccine vectors was suggested several years ago, and to date some partial success has been reported. Clark et al [10] expressed Campylobacter jejuni antigen CjaA in E. tenella and whilst birds immunised with the transgenic parasites were protected (~90 % reduction in C. jejuni in the caeca 2 weeks after challenge, compared to controls) evidence of immunological recognition of the antigen by the chicken was inconclusive. Moreover, Liu et al [11] generated parasites expressing the M2 protein of the avian influenza virus, but found no evidence of antibody or cellular responses.…”
Section: Discussionmentioning
confidence: 99%
“…Starting plasmid pCIT_CjaA [10] contained the mCitrine coding sequence directly downstream of the 5’ Et-Mic1 promoter, and a second expression cassette where the viral genes of interest could be cloned downstream of either the 5’ Et-Actin or 5’ Et-TIF promoter region (Fig. 1).…”
Section: Methodsmentioning
confidence: 99%
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“…Additionally, an effective chicken vaccine should induce a rapid and strong immune response, yet due to the short life span of broiler chickens the birds should be immunized during the first week of life when the avian immune system is immature. A recent test of subunit vaccines that consisted of conserved Campylobacter antigens delivered by attenuated Salmonella strains, Eimeria or nanoparticles, generated promising results [Annamalai et al, 2013;Buckley et al, 2010;Clark et al, 2012;Layton et al, 2011;Łaniewski et al, 2012;Wyszyńska et al, 2004]. Several detailed reviews recapitulating recent approaches to control Campylobacter in poultry via vaccination have been published within the last 5 years [Curtiss et al, 2007;de Zoete et al, 2007;Jagusztyn-Krynicka et al, 2009;Lin, 2009].…”
mentioning
confidence: 99%
“…Both proteins have been intensively studied as chicken vaccine candidates [Buckley et al, 2010;Clark et al, 2012;Layton et al, 2011;Łaniewski et al, 2012;Wyszyńska et al, 2004].…”
mentioning
confidence: 99%