Ein diuretisch wirksamer Stoff aus Wacholder (Juniperus communis L.)

Jankü, I; Háva, M; Motl, O.

doi:10.1007/bf02157448

Cited by 17 publications

(7 citation statements)

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“…So far the essential oil has been considered to be the main biologically active fraction of the drug. Since Janku et al (1957) demonstrated that one of the oil components, terpinen-4-ol, produced diuretic activity, these data have been noted in every competent textbook of phytopharmacy (Weiss, 1985;Wagner, 1988;Wichtl, 1994).…”

Section: Introductionmentioning

confidence: 91%

Time-dependent diuretic response in rats treated with Juniper berry preparations

1998

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The infusion and the essential oil of juniper berries (Juniperus communis L.) as well as terpinen‐4‐ol were tested for diuresis response in rats. GC analysis of the oil obtained from the drug sample revealed that the ratio between the pinene fraction and terpinen‐4‐ol was 5:1. In a 1 day experiment the effect of diuresis reduction was observed and compared with the effect of vasopressin (ADH). The effect of the smallest dose of ADH (0.004 IU/100 g b.w.) intraperitoneally administered was comparable to the effect of a 10% drug infusion and 0.1% essential oil solution, while the effect of 0.4 IU/100 g b.w. of ADH was comparable to that of a 0.01% solution of terpinen‐4‐ol. During a 3 day experiment diuresis was stimulated after the second application and especially after the third application of test solutions. Among tested preparations a 10% drug infusion exerted the most considerable diuretic activity. After 72 h, i.e. three oral doses of 5 mL/100 g b.w. of drug infusion, the cumulative urine volume was 44% above the control value. The results suggest that the diuretic activity of juniper berries cannot be attributed only to the essential oil but also to hydrophilic drug constituents. Copyright © 1998 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 91%

Time-dependent diuretic response in rats treated with Juniper berry preparations

1998

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“…Combinations of small doses were no more effective than juniper berry alone. In 1957, Janku and co-workers [22] demonstrated that 1 mllkg of juniper berry oil injected subcutaneously into white rats produced a significant level of diuresis after 4 and 24 hours compared to controls. Terpinen-4-01 isolated from the oil was injected at a dose of 0.1 ml and this had almost twice the diuretic activity demonstrated by the oil (1 ml/kg).…”

Section: Pharmacology and Usesmentioning

confidence: 98%

Juniperus Species

Corrigan¹

1993

Adverse Effects of Herbal Drugs 2

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BotanyThe junipers constitute a genus of about 60 species of conifers of the family Cupressaceae growing in the northern hemisphere. The most significant species are Juniperus communis ChemistryThe berries of J. communis are known to contain up to 3.4% of volatile oil. This oil consists mainly of monoterpenes such as a-pinene, myrcene, sabinene, a-thujene, /J-pinene, l,4-cineole, and the alcohol terpinen-4-01 [2]. Diterpene acids have also been reported as have sesquiterpenes such as caryophyllene and cadinene [2]. A variety of cathechin-based condensed tannins have been isolated [3]. Maarkanen et al. [4] isolated the lignan desoxypodophyllotoxin and its isomer desoxypicropodophyllotoxin from a chloroform extract of "juniper" berries but Fitzgerald et al. [5] noted that J. communis gave negative tests for the presence of tumour-damaging lignans (including podophyllotoxin and deoxypodophyllotoxin). These workers reported the presence of these lignans from J. sabina (0.25%), J. virginiana (0.1 %), and J. scopulorum (0.17%) among others [6]. They found that the leaves of male plants contained podophyllotoxin while those of the female contained deoxypodophyllotoxin or podophyllotoxin depending on the species [6]. In the case of J. sabina var. tamariscifolia the leaves of the male plant yielded podophyllotoxin, while those of the female plant yielded deoxypodophyllotoxin, as did the berries of the same plant. However the wood was inactive in bioassays and yielded no lignans [5]. Serebryakova and colleagues [7] reported that J. depressa and J. oxycedrus were devoid of lignans, but that J. foetidissima contained deoxypodophyllotoxin [7].

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“…, Juniperus recurva and Juniperus squamata . Among these plants, the various biofunctions of Juniperus communis have been fully studied [ 12 , 13 , 14 , 15 ]. Juniperus indica Bertol also called black Juniper [ 16 ] was reported to have antimicrobial activity [ 17 ] and cytotoxic activity against brine shrimp eggs [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade

et al. 2020

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Oral cancer—a type of head and neck cancer—is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed. Juniperus indica Bertol is a plant of the Juniperus genus often used as a treatment in traditional medicine due to its anti-inflammatory, antibacterial and diuretic functions. The biofunctions of Juniperus indica Bertol including its anticancer potential, have not been fully explored. As a result, the aim of this research was to investigate the anticancer activity of Juniperus indica Bertol extract (JIB extract) and determine whether JIB extract has synergistic effects with cisplatin in oral cancer. These results are the first to demonstrate that JIB extract exhibits anticancer capacity and synergizes with cisplatin to treat oral cancer. Our findings indicate that JIB extract has a potential to develop anticancer agent and chemo therapeutic adjuvant for oral cancer.

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Ein diuretisch wirksamer Stoff aus Wacholder (Juniperus communis L.)

Cited by 17 publications

References 0 publications

Time-dependent diuretic response in rats treated with Juniper berry preparations

Time-dependent diuretic response in rats treated with Juniper berry preparations

Juniperus Species

Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade

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