Ein neuartiges pH-empfindliches MRI-Kontrastmittel

Zhang, Shanrong; Wu, Kaigui; Sherry, A. Dean

doi:10.1002/(sici)1521-3757(19991102)111:21<3382::aid-ange3382>3.0.co;2-m

Cited by 26 publications

(6 citation statements)

References 20 publications

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“…1 H NMR spectra were recorded on a JOEL Eclipse 270 spectrometer operating at 270.17 MHz, a Varian Mercury 300 spectrometer operating at 299.95 MHz and a Bruker Avance III spectrometer operating at 400.13 MHz. 13 C NMR spectra were obtained using a Bruker Avance III spectrometer operating at 100.61 MHz. Longitudinal relaxation times were measured using the inversion recovery method on a MRS-6 NMR analyzer from the Institut "Jožef Stefan", Ljubljana, Slovenjia operating at 20 MHz.…”

Section: Methodsmentioning

confidence: 99%

“…[4] A pH responsive T 1 -shortening contrast agent could offer a minimally invasive and highly practical approach to mapping of tissue pH so it is hardly surprising that a large number of pH sensitive MRI contrast agents have been reported. [5][6][7][8][9][10][11][12][13] Typically, Gd 3 + -based complexes used to relax bulk water have relatively low T 1 relaxivities. Relaxivity is defined as the increase in water proton relaxation rate per unit concentration of contrast agent and is a measure of the effective-Abstract: The design of effective pH responsive MRI contrast agents is a key goal in the development of new diagnostic methods for conditions such as kidney disease and cancer.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16][17][18] Examples of contrast agents that respond to pH through changes in each of these parameters have been reported, [5] but the only agent actually used to image tissue pH to date is Gd1 (see below). [12,13] Although Gd1 exhibits a relatively small a change in relaxivity over a physiologically relevant pH range, it has been used successfully in vivo to generate pH maps of kidneys and tumors in small animals. [19][20][21] The mechanism by which Gd1 operates as a pH responsive agent is unique among responsive Gd 3 + agents and stems from the presence of the phosphonate groups of the pendant arms.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Relaxometric Studies of a Dendrimer‐Based pH‐Responsive MRI Contrast Agent

Ali

Woods

Caravan

et al. 2008

Chemistry A European J

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107

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The design of effective pH responsive MRI contrast agents is a key goal in the development of new diagnostic methods for conditions such as kidney disease and cancer. A key factor determining the effectiveness of an agent is the difference between the relaxivity of the "on" state compared to that of the "off" state. In this paper, we demonstrate that it is possible to improve the pH-responsive action of a low molecular weight agent by conjugating it to a macromolecular construct. The synthesis of a bifunctional pH responsive agent is reported. As part of that synthetic pathway we examine the Ing-Manske reaction, identifying an undesirable by-product and establishing effective conditions for promoting a clean and effective reaction. Reaction of the bifunctional pH responsive agent with a G5-PAMAM dendrimer yielded a product with an average of 96 chelates per dendrimer. The relaxivity of the dendrimer conjugate rises from 10.8 mM(-1) s(-1) (pH 9) to 24.0 mM(-1) s(-1) (pH 6) per Gd(3+) ion. This more than doubles the relaxivity pH response, Deltar(1), of our agent from just 51 % for the original low molecular weight chelate to 122 % for the dendrimer.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and Relaxometric Studies of a Dendrimer‐Based pH‐Responsive MRI Contrast Agent

Ali

Woods

Caravan

et al. 2008

Chemistry A European J

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107

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“…1 Opposed to structural imaging is functional MRI with ''smart'' contrast agents that report on various parameters, such as pH, temperature or parameters that are responsive to light. [2][3][4][5][6][7][8][9] Light is a particularly beneficial stimulus, because it can be applied non-invasively with high spatiotemporal resolution, during MRI scans. 10,11 Contrast switching with light in soft or heterogeneous materials and in living tissues opens a number of applications in chemical engineering and medicine, such as in situ studies of processes during catalytic reactions, 12,13 and the characterisation of mass transport in heterogeneous polymers or elastomers 13 including the monitoring of controlled drug delivery from polymer gels.…”

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confidence: 99%

Dendronised Ni(ii) porphyrins as photoswitchable contrast agents for MRI

Dommaschk

Gröbner

Wellm

et al. 2019

Phys. Chem. Chem. Phys.

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“…An early pH‐sensitive agent was GdDOTA‐4AMP 15. This agent was used to map pH values in vivo in renal‐acidosis16 and brain‐tumor17 models.…”

Section: Methodsmentioning

confidence: 99%

Smart Nanomachines Based on DNA Self‐Assembly

Chen

Wang

Ding

2013

Small

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DNA-based nanomachines are self-assembled DNA superstructures that harness chemical free energy to perform mechanical work. The development of DNA machines has benefited greatly from the achievements in both structural and dynamic DNA nanotechnology. In this review, the configurations of DNA machines, fuel systems, and operations are discussed to outline the evolving paths of DNA machines. The focus is on the smart mechanical behavior of DNA machines, from the standpoint of upgrading the complexity of DNA nanostructures, cooperative activation of multimachinary systems, and the establishment of a network of the mechanical states. In the end, the challenges are highlighted and possible solutions are proposed to push forward smart DNA nanomachines, with the goal of creating biomimicking systems. Insights are also provided into the potential applications of the DNA machines with designable intelligence.

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Ein neuartiges pH-empfindliches MRI-Kontrastmittel

Cited by 26 publications

References 20 publications

Synthesis and Relaxometric Studies of a Dendrimer‐Based pH‐Responsive MRI Contrast Agent

Synthesis and Relaxometric Studies of a Dendrimer‐Based pH‐Responsive MRI Contrast Agent

Dendronised Ni(ii) porphyrins as photoswitchable contrast agents for MRI

Smart Nanomachines Based on DNA Self‐Assembly

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