EIN4 and ERS2 Are Members of the Putative Ethylene Receptor Gene Family in Arabidopsis

Ma, Jianhua; Sakai, Hajime; Nourizadeh, Saeid; Chen, Qianhong G.; Bleecker, Anthony B.; Ecker, Joseph R.; Meyerowitz, Elliot M.

doi:10.2307/3870643

Cited by 104 publications

(152 citation statements)

References 17 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…In contrast, dominant gain-of function mutations in the ethylene receptor genes result in ethylene insensitivity, characterized by the absence of the triple response, slightly larger rosette leaves, and delayed senescence (2). Gain-of function alleles encode amino acid substitutions residing in the ethylenebinding domain (5)(6)(7)(8). An example is the etr1-1 mutation, which blocks ethylene binding, resulting in ethylene insensitivity (13).…”

mentioning

confidence: 99%

“…The isolation of mutants having an altered triple-response phenotype has uncovered an ethylene signaling pathway that leads from ethylene binding to changes in gene expression (4). Perception of ethylene is carried out by receptors related to the two-component histidine protein kinase family primarily found in prokaryotes (5)(6)(7)(8). The five ethylene receptors in Arabidopsis (ETR1, ERS1, EIN4, ETR2, and ERS2) exhibit redundancy and are negative regulators of ethylene responses (9)(10)(11).…”

mentioning

confidence: 99%

See 1 more Smart Citation

REVERSION-TO-ETHYLENE SENSITIVITY1 , a conserved gene that regulates ethylene receptor function in Arabidopsis

Resnick

Wen

Shockey

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

189

276

View full text Add to dashboard Cite

Arabidopsis thaliana has five ethylene hormone receptors, which bind ethylene and elicit responses critical for plant growth and development. Here we describe a negative regulator of ethylene responses, REVERSION-TO-ETHYLENE SENSITIVITY1 ( RTE1 ), which regulates the function of at least one of the receptors, ETR1 , in Arabidopsis . RTE1 was identified based on the ability of rte1 mutations to suppress ethylene insensitivity of the dominant gain-of-function allele etr1-2 . rte1 loss-of-function mutants have an enhanced ethylene response that closely resembles the etr1 null phenotype. The etr1 rte1 double null mutant is identical to the etr1 and rte1 single null mutants, suggesting that the two genes act in the same pathway. rte1 is unable to suppress the etr1-1 gain-of-function allele, placing RTE1 at or upstream of ETR1 . rte1 also fails to suppress gain-of-function mutations in each of the four other ethylene receptor genes. RTE1 encodes a previously undescribed predicted membrane protein, which is highly conserved in plants and protists but absent in fungi and prokaryotes. Ethylene treatment induces RTE1 expression, and overexpression of RTE1 confers reduced ethylene sensitivity that partially depends on ETR1 . These findings demonstrate that RTE1 is a negative regulator of ethylene signaling and suggest that RTE1 plays an important role in ETR1 function.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

REVERSION-TO-ETHYLENE SENSITIVITY1 , a conserved gene that regulates ethylene receptor function in Arabidopsis

Resnick

Wen

Shockey

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

189

276

View full text Add to dashboard Cite

show abstract

“…efr-1 6 , ers1-10 (a weak gain-of-function mutant; ERS, ethylene receptor-related gene family member) 26 , ein4-1 (a gain-of-function mutant; EIN4, ethylene receptor-related gene family member) 27 , wei7-4 (a loss-of-function mutant; WEI7, involved in ethylene-mediated auxin increase) 28 , eicbp.b ( camta 1–3 ; SALK_108806; EICBP.B, an ethylene-induced calmodulin-binding protein) 29 , pab2/4 18 and pab2/8 18 were previously described. efr7 (SALK_205018; ERF7, a homologue of the ethylene responsive TF gene ERF1 ) and gcn2 (GABI_862B02) were from the Arabidopsis Biological Resource Center (ABRC).…”

Section: Methodsmentioning

confidence: 99%

Global translational reprogramming is a fundamental layer of immune regulation in plants

Greene

Yoo

et al. 2017

Nature

205

212

View full text Add to dashboard Cite

In the absence of specialized immune cells, the need for plants to reprogram transcription to transition from growth-related activities to defence is well understood1, 2. However, little is known about translational changes that occur during immune induction. Using ribosome footprinting (RF), we performed global translatome profiling on Arabidopsis exposed to the microbe-associated molecular pattern (MAMP) elf18. We found that during this pattern-triggered immunity (PTI), translation was tightly regulated and poorly correlated with transcription. Identification of genes with altered translational efficiency (TE) led to the discovery of novel regulators of this immune response. Further investigation of these genes showed that mRNA sequence features are major determinants of the observed TE changes. In the 5′ leader sequences of transcripts with increased TE, we found a highly enriched mRNA consensus sequence, R-motif, consisting of mostly purines. We showed that R-motif regulates translation in response to PTI induction through interaction with poly(A)-binding proteins. Therefore, this study provides not only strong evidence, but also a molecular mechanism for global translational reprogramming during PTI in plants.

show abstract

“…For example, adverse environmental conditions enhance ethylene production, and thereby restrain growth (3,4). Ethylene is perceived by the ETR1 family of ethylene receptors (6)(7)(8)(9)(10). In the absence of ethylene, ETR1 activates CTR1, a Ser/Thr kinase (closely related to the RAF kinases) that is a negative regulator of ethylene signaling (11,12).…”

mentioning

confidence: 99%

The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes

Achard

Baghour

Chapple

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

342

254

View full text Add to dashboard Cite

The length of the Arabidopsis thaliana life cycle depends on the timing of the floral transition. Here, we define the relationship between the plant stress hormone ethylene and the timing of floral initiation. Ethylene signaling is activated by diverse environmental stresses, but it was not previously clear how ethylene regulates flowering. First, we show that ethylene delays flowering in Arabidopsis, and that this delay is partly rescued by loss-of-function mutations in genes encoding the DELLAs, a family of nuclear gibberellin (GA)-regulated growth-repressing proteins. This finding suggests that ethylene may act in part by modulating DELLA activity. We also show that activated ethylene signaling reduces bioactive GA levels, thus enhancing the accumulation of DELLAs. Next, we show that ethylene acts on DELLAs via the CTR1-dependent ethylene response pathway, most likely downstream of the transcriptional regulator EIN3. Ethylene-enhanced DELLA accumulation in turn delays flowering via repression of the floral meristem-identity genes LEAFY (LFY) and SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1). Our findings establish a link between the CTR1/EIN3-dependent ethylene and GA-DELLA signaling pathways that enables adaptively significant regulation of plant life cycle progression in response to environmental adversity.floral transition ͉ Arabidopsis thaliana ͉ LFY ͉ gibberellin F loral initiation is a major step in the plant life cycle (1). Accordingly, plants have evolved mechanisms for regulating the timing of floral initiation. These mechanisms permit an adaptively significant integrated response to multiple interacting factors (both internal and external to the plant). In essence, the endogenous developmental competence of plants to flower is integrated with environmental cues that signal the onset of conditions favorable for reproductive success (2).In this article, we describe the role of the gaseous phytohormone ethylene in the regulation of floral initiation. Ethylene is already known to modulate Arabidopsis vegetative environmental growth responses (3-5). For example, adverse environmental conditions enhance ethylene production, and thereby restrain growth (3, 4). Ethylene is perceived by the ETR1 family of ethylene receptors (6-10). In the absence of ethylene, ETR1 activates CTR1, a Ser/Thr kinase (closely related to the RAF kinases) that is a negative regulator of ethylene signaling (11,12). Downstream of CTR1 are several positive regulators of ethylene response: EIN2 (a membrane-associated protein whose function is not clear; ref. 13) and the EIN3 and EIN3-like (EIL) transcription factors (14, 15). EIN3 regulates ethylene-responsive genes (6, 15), whereas overexpression of EIN3 results in the constitutive activation of ethylene responses (14). Furthermore, ethylene response depends on EIN3 stability. In the absence of ethylene, EIN3 degradation is promoted by a specific Skp1-cullin-F box protein (SCF) E3 ubiquitin ligase (SCF EBF1/EBF2 ) that targets EIN3 for destruction by the proteasome (16-18). Howev...

show abstract

EIN4 and ERS2 Are Members of the Putative Ethylene Receptor Gene Family in Arabidopsis

Cited by 104 publications

References 17 publications

REVERSION-TO-ETHYLENE SENSITIVITY1 , a conserved gene that regulates ethylene receptor function in Arabidopsis

REVERSION-TO-ETHYLENE SENSITIVITY1 , a conserved gene that regulates ethylene receptor function in Arabidopsis

Global translational reprogramming is a fundamental layer of immune regulation in plants

The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes

Contact Info

Product

Resources

About