Eine Sonderform der chronischen Glomerulonephritis

Maintz, J.; Elema, Jd; Henningsen, B.; Bläker, F; Bünger, Paul

doi:10.1055/s-0028-1107595

Cited by 12 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A benign prognosis of this nephropathy has been reported in seriesconcerningchildren [8,13,15,17] as well as in some other studies [1,3,6,16,18,19,20]. How ever, in different series, especially in recent ones, relatively high incidences (19-36%) of renal dysfunction have been described [4.…”

Section: Discussionmentioning

confidence: 99%

“…This nephropathy was considered as a be nign disorder, especially in earlier reports about the disease [1,3,8,[15][16][17][18][19][20]. Recently, however, a slowly progressive course to renal failure has occasionally been described [9,10,[21][22][23][24][25], and some clinical and histological parameters, such as hypertension, marked proteinuria or glomerular and tubulointerstitial sclerotic lesions have been recognized as being of value in predicting an unfavorable outcome.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

IgA Nephropathy: Prognostic Significance of Proteinuria and Histological Alterations

Kobayashi

Tateno

Hiki

et al. 1983

Nephron

138

View full text Add to dashboard Cite

A retrospective study of 166 patients with IgA nephropathy was undertaken to clarify possible correlations between clinical and histological features, and the severity and prognosis of the disease. At the time of biopsy, impaired renal function, with creatinine clearance (C_cr) below 90 ml/min was found in 61 cases. At the final examination, after a mean follow-up period of 34 months, 82 patients had impaired renal function, 12 of these patients went into terminal renal failure requiring hemodialysis treatment. The presence of proteinuria of more than 1.0 g/day was closely correlated with impairment of renal function both at the time of biopsy and at the final observation. An unfavorable outcome was also anticipated in the presence of hypertension. In contrast, microhematuria, macrohematuria or high serum IgA levels did not appear to be related to the outcome. Histologically, sclerotic lesions such as mesangial or global sclerosis, interstitial fibrosis and tubular atrophy, and some active changes such as mesangial hypercellularity and tuft adhesion were more frequent and severe in patients with impaired renal function. Impressive localization of IgA and C3 in the mesangium as well as in capillary loops was observed more often in these patients. These results clearly indicate that IgA nephropathy may follow a slowly progressive course in about half of the patients, and that marked proteinuria and severe histological changes appear to correlate closely with an unfavorable course.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

IgA Nephropathy: Prognostic Significance of Proteinuria and Histological Alterations

Kobayashi

Tateno

Hiki

et al. 1983

Nephron

138

View full text Add to dashboard Cite

show abstract

“…Although a progressive deterioration of GFR has been known from the early descriptions [4,17,20], most authors stressed the favorable outcome of IgA-GN [15,21,33,35,50,52]. Although a progressive deterioration of GFR has been known from the early descriptions [4,17,20], most authors stressed the favorable outcome of IgA-GN [15,21,33,35,50,52].…”

Section: Discussionmentioning

confidence: 99%

“…Four patients described by Berger in whom the onset of recurrent haematuria and proteinuria was between the ages of 10 and 15 years required dialysis between the ages of 17 and 32 years [7]. [7,13,28,32,35,38,41,46] 393 60 66 (17%)" 29 (7%) Adults [5,12,15,17,19,21,22,26,27,33,45,48,50,51 [13,14,17,28,45,54,56] or its polymers [31], the occasional IgA deposition in skin [3,49], and the clinical and immunopathological recurrence of the disease after transplantation in about 50% of all cases [7,19]. From these observations we conclude that prospective long-term studies with regular clearance measurements are necessary for better evaluation of the prognoses of children with IgA-GN.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic mesangial IgA-glomerulonephritis in childhood

et al. 1980

View full text Add to dashboard Cite

Nineteen out of 83 children with asymptomatic haematuria were classified as having IgA glomerulonephritis, characterized by diffuse mesangial deposition of IgA in the absence of systematic disease. Different histological patterns were observed: i.e., minor glomerular lesions (5 cases), focal and segmental proliferative glomerulonephritis (8 cases) and diffuse proliferative glomerulonephritis (6 cases). Recurrent gross haematuria is the clinical hallmark of the disease. Proteinuria was present in 14 children and exceeded 1 g/m2/day in 3 patients. Clinico-pathological correlations showed a close relation between the degree of proteinuria and the histological lesions. Serum IgA levels were elevated in 3 children. Glomerular filtration rate remained above 80 ml/min/1.73 m2 in a 1 to 9 year follow-up.

show abstract

“…: Since Berger's original description, several communications have appeared [2,3,5,6,8,10,15,18,19,20,21,23,26,27] in which the new clinico-pathological entity is referred to as Berger's disease. The etiology is unknown.…”

mentioning

confidence: 99%

IgA glomerulonephritis

Nagy

Brasch

Süle

et al. 1979

International Urology and Nephrology

View full text Add to dashboard Cite

Renal biopsy specimens from 204 patients with glomerulonephritis or nephrotic syndrome have been studied. In ten of the patients not suffering from acute poststreptococcal glomerulonephritis, systemic lupus erythematosus or Schönlein-Henoch syndrome, diffuse, selective mesangial IgA deposition was observed. Clinically, persistent microscopic haematuria, mild proteinuria and, except in one patient, normal renal function were found. Light microscopically the histological picture was dominated by a diffuse or focal increase in volume of the mesangial matrix, and mild mesangial cell proliferation. Exceptionally, there was also crescent formation. Immunofluorescence revealed large IgA, IgG and C3 deposits, as well as small IgM and fibrinogen deposits in the mesangial glomeruli. The authors' assumption that immunocomplexes containing a secretory component might be implicated in the pathomechanism of Berger's disease, could not be proved.

show abstract

Eine Sonderform der chronischen Glomerulonephritis

Cited by 12 publications

References 10 publications

IgA Nephropathy: Prognostic Significance of Proteinuria and Histological Alterations

IgA Nephropathy: Prognostic Significance of Proteinuria and Histological Alterations

Idiopathic mesangial IgA-glomerulonephritis in childhood

IgA glomerulonephritis

Contact Info

Product

Resources

About