The confinement of reinforced concrete (RC) compression members by fiber-reinforced polymers (FRPs) is an effective measure for the strengthening and retrofitting of existing structures. Thus far, extensive research on the stress–strain behavior and ultimate limit state design of FRP-confined concrete has been conducted, leading to various design models. However, these models are significantly different when compared to one another. In particular, the use of certain empirical efficiency and reduction factors results in various predictions of load-bearing behavior. Furthermore, most experimental programs solely focus on plain concrete specimens or demonstrate insufficient variation in the material properties. Therefore, this paper presents a comprehensive experimental study on plain and reinforced FRP-confined concrete, limited to circular cross sections. The program included 63 carbon FRP (CFRP)-confined plain and 60 CFRP-confined RC specimens with a variation in the geometries and in the applied materials. The analysis showed a significant influence of the compressive strength of the confined concrete on the confinement efficiency in the design methodology, as well as the importance of the proper determination of individual reduction values for different FRP composites. Finally, applicable experimental test results from the literature were included, enabling the development of a modified stress–strain and ultimate condition design model.