Einführung in die Akustik

Trendelenburg, Ferdinand

doi:10.1007/978-3-642-86495-7

Cited by 54 publications

(15 citation statements)

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“…Thus, it is like ly that the sympathetic decentralization of the submaxillary gland results in a decrease of the enzyme activity or alternatively, an interference with the uptake or binding mecha nism of dopamine by the particle. The multiphasic change in specific activity of nor adrenaline in the rat heart after administration of the labelled catecholamine (18)(19)(20) pro vides direct evidence for a division of catecholamine stores postulated first by Trendelenburg (21). The present results show that disappearance of dopamine-"C from the salivary glands after the injection is of more than two phases.…”

Section: Discussionsupporting

confidence: 69%

The Uptake of Dopamine-14c and Its Conversion to Noradrenaline-14c in Rats

1967

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Section: Discussionsupporting

confidence: 69%

The Uptake of Dopamine-14c and Its Conversion to Noradrenaline-14c in Rats

1967

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“…Among the amines listed in Table 4 the last 5 compounds exert an important indirect effect, and two of them-tyramine and amphetamine-act only indirectly (Trendelenburg, 1963). Our observations that three of these amines were not taken up by a cocaine-sensitive mechanism seems to contradict the supposition that the antagonizing effect of cocaine is due to inhibition of the uptake of these amines before they release noradrenaline (Trendelenburg, 1961). Ross & Renyi (1966a) proposed that the noradrenaline released by the indirectly-acting amines emanates from a small extraneuronal store, possibly located in the carrier in the neuron membrane.…”

Section: Discussionmentioning

confidence: 76%

Cocaine-sensitive uptake of sympathomimetic amines in nerve tissue

Ross¹,

Renyi²,

Brunfelter³

1968

Journal of Pharmacy and Pharmacology

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The uptake of [3H]octopamine, [3H]norephedrine and [3H]phenylethanolarnine in slices of cerebral cortex and heart of the mouse was investigated. Cocaine inhibited the uptake of octopaniine but had no effect on that of the other two arnines, whose uptake seems to be a pure physico-chemical partition between the tissue and the solution. Together with previous results, these indicate that the cocaine-sensitive uptake is linked with the hydroxyl groups in the benzene nucleus and particularly with that in the rneta position. The results bear out the view that the potentiating effect of cocaine on the direct effect of sympathomimetic amines is due to inhibition of the uptake of the amines in sympathetic nerves, but they contradict the assumption that the antagonizing effect of cocaine on the indirect action of the amines is due to inhibition of the amine uptake.N previous experiments it was found that the uptake of tritiated I sympathomimetic amines in brain slices which had been incubated with the amines for a short time was greatly reduced by cocaine and desipramine but not by reserpine (Ross & Renyi, 1966a, b, c). This indicates that under these conditions the uptake of the amines via the neuron membranes of adrenergic nerves was the most important factor governing the amine accumulation. The rate of uptake was found to be dependent on the chemical structure of the amines. For instance noradrenaline and dopamine were taken up with similar velocities while tyramine showed a slower uptake. (-)-Amphetamine was not actively taken up at all.To obtain more information the investigation has been extended with three amines, namely [3H]octopamine, [3H]norephedrine and [3H]phenylethanolamine.

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“…Evidence for this is the sup pression of a positive inotropic response of atria after reserpine treatemnt and its restoration on incubation in vitro with noradrenaline. It has been shown that treatment with reser pine markedly reduces the effects of substances that act primarily by releasing endogenous catecholamine from the heart (25,26).…”

Section: Methodsmentioning

confidence: 99%