Einleitung: Jugendforschung in der Bundesrepublik

Reimann, Helga; Reimann, Horst

doi:10.1007/978-3-322-95703-0_1

Cited by 2 publications

(8 citation statements)

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“…Leukocytes from one CB17 +/+ mouse, one scid (Ig <50 ng/ml), one "leaky" scid (Ig 1.1 yg/ml) and three 10 Human leukocytes in the offspring of scid-hu/PBL 1737 scid, "leaky" scid and seid-humo")…”

Section: Cytofluorimetric Analysis Of Murine Cellsmentioning

confidence: 99%

Human peripheral blood leukocytes transplanted on CB17 scid‐scid mice are transferred to their offspring

et al. 1992

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Severe combined immunodeficient (scid) mice are deficient in functional T cells and B cells. Hence, scid mice reconstituted with human peripheral blood leukocytes (scid-huPBL) provide an excellent model for analysis of the human immune response under in vivo conditions. We have investigated this model further by analyzing human immune responses in the progeny of scid-huPBL (termed scid-humo). We find markedly elevated levels of human immunoglobulins (Ig) in the serum of scid-humo for more than 12 weeks indicating materno-fetal transfer of human B lymphocytes. Consistent with this finding we obtained evidence for the existence of human lymphocytes in scid-humo. Murine Ig levels in scid-humo were also elevated and surface Ig-expressing cells (probably B cells) were demonstrable. In this respect scid-humo resembled "leaky" scid. In contrast to "leaky" scid, scid-humo accepted transfer of human blood leukocytes. Not only leukocytes from autologous but also those from heterologous donors were accepted. Human Ig levels in scid-humo increased more rapidly as compared to normal scid mice. Thus, despite these increased B cell activities in scid-humo, transferred human leukocytes were not affected indicating that materno-fetal transfer of human cells had caused tolerization or conditioning. This is in contrast to scid mice in which elevated Ig levels correlate with increased failure rates of reconstitution with human blood leukocytes. We propose that scid-humo provide an improved model for studying the human immune responses in an in vivo setting.

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Section: Cytofluorimetric Analysis Of Murine Cellsmentioning

confidence: 99%

Human peripheral blood leukocytes transplanted on CB17 scid‐scid mice are transferred to their offspring

et al. 1992

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“…Occurrences of hydration forms and caves have been documented in many places around the world, both in natural (e.g., Woodward Co. in Oklahoma, Ottawa Co. in Ohio, Culberson Co. in Texas, and Eddy Co. in New Mexico in the USA, Alberta in Canada, and Tripolitania in Libya) and artificial exposures of anhydrite rocks [3,4,[15][16][17]19,22,[39][40][41][42][43][44][45][46][47][48][49][50]. However, so far, only four places are known with remarkable amounts of these forms creating spectacular hydration landscape: most notably at environs of Walkenried at the south margin of Harz Mts.…”

Section: Introductionmentioning

confidence: 99%

“…However, so far, only four places are known with remarkable amounts of these forms creating spectacular hydration landscape: most notably at environs of Walkenried at the south margin of Harz Mts. in Germany [2,4,6,15,47,49,[51][52][53], in the abandoned quarry at Pisky in Ukraine [13,18,[54][55][56][57][58][59][60], on the small Alebastrovyye Islands in Russia [5] and at the abandoned quarry at Dingwall in Canada [6][7][8][9]14,48,61]. Among them, the site at Dingwall in Canada (Figures 1 and 2a-e), studied by the authors, is the largest in number and size of hydration forms and caves.…”

Section: Introductionmentioning

confidence: 99%

“…The other authors called them gypsum bubbles due to their predominantly dome-like shape [6,17,39,48], mounds [5,16], and blisters [42,48], but because of their similarity to the characteristic low wall-less army tents-also tents or A-tents [48,62]. Based on the observation of changes in the form shape over time (Figure 2e,f) [7,9], it has been proposed that the shape of the forms from Dingwall will change from a dome (bubble) to a tepee (tent [48]), similar to the case of the hydration form called Waldschmiede in Germany [4,49]. An intermediate form similar to both was called the rounded tent [48].…”

Section: Introductionmentioning

confidence: 99%

“…Another hydration form of extraordinary size is the Ramesh Cave in the Dingwall quarry, with dimensions of 9.95 × 4.10 × 1.32 m [8]. Documented sizes of hydration caves are often changeable and grow or decrease with time [4,9,49]. A detached rock layer is commonly from a few cm to several tens of cm thick [5,6,18,51,53,61], and in extreme cases, in side parts of forms 200 cm thick [9].…”

Section: Introductionmentioning

confidence: 99%

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Morphology of Dome- and Tepee-Like Landforms Generated by Expansive Hydration of Weathering Anhydrite: A Case Study at Dingwall, Nova Scotia, Canada

et al. 2022

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The gypsum-anhydrite rocks in the abandoned quarry at Dingwall (Nova Scotia, Canada) are subjected to physical and chemical weathering, including hydration of the anhydrite, i.e., its transformation into secondary gypsum under the influence of water. This process is known to lead to the localized volume increase of the rock and the formation of spectacular hydration landforms: domes, tepees and ridges. Cavities appearing in the interior of these domes are often unique hydration caves (Quellungshöhlen in German). For the first time, this paper gives detailed geomorphometric characteristics of the 77 dome- and tepee-like hydration landforms growing today at Dingwall based on their digital surface models and orthophotomaps, made with the method of photogrammetry integrated with direct measurements. The length of hydration landforms varies from 1.86 to 23.05 m and the relative height varies from 0.33 to 2.09 m. Their approximate shape in a plan view varies from nearly circular, through oval, to elongated with a length-to-width ratio rarely exceeding 5:2. Length, width and relative height are characterized by moderate mutual correlation with proportional relations expressed by linear equations, testifying that the hydration landforms generally preserve the same or very similar shape independent of their sizes. The averaged thickness of the detached rock layer ranges from 6 to 46 cm. The size of the forms seems to depend on this thickness—the forms larger in extent (longer) generally have a thicker detached rock layer. Master (and other) joints and, to a lesser extent, layering in the bedrock influence the development of hydration landforms, particularly by controlling the place where the entrances are open to internal cavities or caves. Three structural types of the bedrock influencing the growth of hydration forms were recognized: with master joints, with layering and with both of them. The latter type of bedrock has the most complex impact on the morphology of hydration landforms because it depends on the number of master joint sets and the mutual orientation of joints and layering, which are changeable across the quarry. The durability of the hydration forms over time depends, among others, on the density of fractures in the detached rock layer.

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Einleitung: Jugendforschung in der Bundesrepublik

Cited by 2 publications

References 1 publication

Human peripheral blood leukocytes transplanted on CB17 scid‐scid mice are transferred to their offspring

Human peripheral blood leukocytes transplanted on CB17 scid‐scid mice are transferred to their offspring

Morphology of Dome- and Tepee-Like Landforms Generated by Expansive Hydration of Weathering Anhydrite: A Case Study at Dingwall, Nova Scotia, Canada

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