Einsatz von Gonadorelin[6-D-Phe] am Tag 0 oder 12 post inseminationem zur Steigerung der Konzeptionsrate in einer sächsischen Milchviehgroßanlage

Freick, Markus; Weber, Olivier Zaro; Passarge, O.; Neubert, Thomas R

doi:10.15653/tpg-140315

Tierarztl Prax Ausg G

2014

DOI: 10.15653/tpg-140315

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Einsatz von Gonadorelin[6-D-Phe] am Tag 0 oder 12 post inseminationem zur Steigerung der Konzeptionsrate in einer sächsischen Milchviehgroßanlage

Markus Freick¹,

Olivier Zaro Weber²,

O. Passarge³

et al.

Abstract: An increased conception rate was only achieved for the first service of high-yield dairy cows (lactation number ≥ 2) by gonadorelin treatment at day 0. Presumably, the higher incidence of delayed ovulations in this group was treated successfully by gona- dorelin administration.

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Regulation of FSH Synthesis by Differentially Expressed miR-488 in Anterior Adenohypophyseal Cells

Wang

Chen

et al. 2021

Animals

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Gonadotropin-releasing hormone (GnRH), which is synthesized and released by the hypothalamus, promotes the synthesis and secretion of follicle-stimulating hormone (FSH), thereby regulating the growth and reproduction of animals. GnRH analogues have been widely used in livestock production. MiRNAs, which are endogenous non-coding RNAs, have been found to play important roles in hormone regulation and other physiological processes in recent years. However, the roles of miRNAs in GnRH-mediated regulation of FSH secretion have rarely been studied. Herein, we treated bovine anterior adenohypophyseal cells with an exogenous GnRH analogue and found that miR-488 was differentially expressed. Through a combination of TargetScan prediction and dual luciferase reporter analysis, miR-488 was confirmed to be able to target the FSHB gene. Based on this finding, we verified the expression of Fshβ and Lhβ mRNA in the rat adenohypophysis before and after exogenous GnRH treatment in vivo and in vitro. Experiments on rat anterior adenohypophyseal cells showed that overexpression of miR-488 significantly inhibited Fshβ expression and FSH synthesis, while knockdown of miR-488 had the opposite effects. Our results demonstrate that GnRH relies on miR-488 to regulate FSH synthesis, providing additional useful evidence for the significance of miRNAs in the regulation of animal reproduction.

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Regulation of FSH Synthesis by Differentially Expressed miR-488 in Anterior Adenohypophyseal Cells

Wang

Chen

et al. 2021

Animals

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show abstract

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Einsatz von Gonadorelin[6-D-Phe] am Tag 0 oder 12 post inseminationem zur Steigerung der Konzeptionsrate in einer sächsischen Milchviehgroßanlage

Abstract: An increased conception rate was only achieved for the first service of high-yield dairy cows (lactation number ≥ 2) by gonadorelin treatment at day 0. Presumably, the higher incidence of delayed ovulations in this group was treated successfully by gona- dorelin administration.

Cited by 1 publication

References 27 publications

Regulation of FSH Synthesis by Differentially Expressed miR-488 in Anterior Adenohypophyseal Cells

Regulation of FSH Synthesis by Differentially Expressed miR-488 in Anterior Adenohypophyseal Cells

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