Einwirkung von Brom auf aromatische Thioharnstoffe

Regioselective Synthesis, Antimicrobial Evaluation and QSAR Studies of Some 3‐Aryl‐1‐heteroarylindeno[1,2‐c]pyrazol‐4(1H)‐ones

“…The required 2‐arylidene‐1 H ‐indene‐1,3(2 H )‐diones ( 2 ) as starting material were prepared through Knoevenagel condensation of equimolar quantities of 1 H ‐indene‐1,3(2 H )‐dione ( 1 ) with appropriate aromatic aldehydes in ethanol in the presence of catalytic amount of piperidine according to the procedure described in literature . The 2‐hydrazinylbenzo[ d ]thiazole/2‐hydrazinyl‐6‐substituted benzo[ d ]thiazoles ( 3 ) were prepared from benzo[ d ]thiazol‐2‐amine/6‐substitutedbenzo[ d ]thiazol‐2‐amines upon treatment with hydrazine hydrochloride in ethylene glycol, which, in turn, were prepared from aniline/4‐substituted anilines using potassium thiocyanate/bromine according to the procedures detailed in literature . The title indenopyrazoles ( 4 ) were synthesized by stirring the equimolar quantities of 2‐arylidene‐1 H ‐indene‐1,3(2 H )‐diones ( 2 ) and 2‐hydrazinylbenzo[ d ]thiazole/2‐hydrazinyl‐6‐substituted benzo[ d ]thiazoles ( 3 ) in dry pyridine/piperidine at room temperature for 3–4 days in low yields.…”

“…2‐Hydrazinylbenzo[ d ]thiazole/2‐hydrazinyl‐6‐substitutedbenzo[ d ]thiazoles ( 3 ) were prepared from the appropriate benzo[ d ]thiazol‐2‐amine/6‐substitutedbenzo[ d ]thiazol‐2‐amines upon treatment with hydrazine hydrochloride in ethylene glycol, which, in turn, were prepared from the corresponding aniline/4‐substituted anilines using potassium thiocyanate/bromine according to the procedures detailed in literature .…”

Straightforward convergent access to 2-arylated polysubstituted benzothiazoles

“…[21,22] Subsequent Hugershoff cyclization with Br2 yielded the desired 2-amino-4-bromobenzothiazole (2) in excellent yield. [23,24] One-pot iodination of 2, under Sandmeyer conditions, provided 4bromo-2-iodo-benzothiazole 3…”

A Review on Biological Properties and Mixed Ligand Metal Complexes Of 2-Aminobenzothiazoles

“…Hoffmann çalışmasında, 2-aminotiyofenol ile fenilizotiyosiyanatın reaksiyonundan 2anilinobenzotiyazolün sadece oluşumunu belirtmiştir (Şekil 4). 1900'larda Hugerschoff çalışmalarında kloform içerisinde ariltiyoürenin brom katalizörlüğünde halkalandırılması ile 2-aminobenzotiyazollerin sentezini bulmuştur (Şekil 5) [21], [22]. Moleküler brom katalizörlüğünde ariltiyoürelerin halkalanma reaksiyonu "Hugerschoff reaksiyonu" olarak bilinir.…”