Einwirkung von Chlortrifluorid auf organische Verbindungen

Condition-Controlled O-Acylation and N–O Bond Reduction of Hydroximic Acids with Thioacetic Acid

“…The formation of primary amides is an important topic in natural product synthesis and medicinal chemistry for drug discovery (Figure ). Classic methods to access amides include the Schmidt reaction, the hydration of organonitriles, and the direct ammoniation of carboxylic acids and derivatives . In addition, a variety of catalytic strategies have also been developed, such as the amidation of aldehydes and alcohols, the aminocarbonylation of alkynes, the transamidation of amides, and so on.…”